R
Rajarshi Mukherjee
Researcher at University of Liverpool
Publications - 53
Citations - 1916
Rajarshi Mukherjee is an academic researcher from University of Liverpool. The author has contributed to research in topics: Acute pancreatitis & Pancreatitis. The author has an hindex of 20, co-authored 45 publications receiving 1516 citations. Previous affiliations of Rajarshi Mukherjee include National Institute for Health Research & Royal Liverpool University Hospital.
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Journal ArticleDOI
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Rajarshi Mukherjee,Rajarshi Mukherjee,Olga A. Mareninova,Irina V. Odinokova,Irina V. Odinokova,Wei Huang,Wei Huang,Wei Huang,J. A. Murphy,J. A. Murphy,Michael Chvanov,Michael Chvanov,Muhammad A. Javed,Muhammad A. Javed,Li Wen,Li Wen,David Booth,David Booth,Matthew C Cane,Muhammad Awais,Muhammad Awais,Bruno Gavillet,Rebecca M. Pruss,Sophie Schaller,Jeffery D. Molkentin,Alexei V. Tepikin,Alexei V. Tepikin,Ole H. Petersen,Stephen J. Pandol,Ilya Gukovsky,David N. Criddle,David N. Criddle,Anna S. Gukovskaya,Robert Sutton,Robert Sutton +34 more
TL;DR: The mechanism and consequences of MPTP opening are demonstrated to be fundamental to multiple forms of acute pancreatitis and validates the MPTP as a drug target for this disease.
Journal ArticleDOI
Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells
David Booth,David Booth,J. A. Murphy,J. A. Murphy,Rajarshi Mukherjee,Rajarshi Mukherjee,Muhammad Awais,John P. Neoptolemos,Oleg Vsevolodovich Gerasimenko,Alexei V. Tepikin,Ole H. Petersen,Robert Sutton,David N. Criddle +12 more
TL;DR: Investigation of the role of intracellular reactive oxygen species in pancreatic acinar cell injury indicates that alternative strategies to antioxidants are required for oxidative stress in acute pancreatitis.
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Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells
J. A. Murphy,David N. Criddle,Mark W. Sherwood,Michael Chvanov,Rajarshi Mukherjee,Euan McLaughlin,David Booth,Julia Vladimirovna Gerasimenko,Michael Raraty,Paula Ghaneh,John P. Neoptolemos,Oleg Vsevolodovich Gerasimenko,Alexei V. Tepikin,Gary M. Green,Joseph R. Reeve,Joseph R. Reeve,Ole H. Petersen,Robert Sutton +17 more
TL;DR: CCK at physiologic concentrations in the presence of atropine and tetrodotoxin elicits cytosolic Ca(2+) signaling, activates mitochondrial function, and stimulates enzyme secretion in isolated human pancreatic acinar cells, concluding that CCK acts directly on acinar Cells in the human pancreas.
Journal ArticleDOI
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma
Junjie Xiong,Kiran Altaf,Muhammad A. Javed,Wei Huang,Rajarshi Mukherjee,Gang Mai,Robert Sutton,Xubao Liu,Weiming Hu +8 more
TL;DR: A meta-analysis to determine the safety and efficacy of laparoscopic liver resection (LLR) and open liver resections (OLR) for hepatocellular carcinoma found LLR appeared to have a lower incidence of postoperative ascites and patients in the LLR group were found to have shorter hospital stay.
Journal ArticleDOI
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis
Wei Huang,David Booth,Matthew C Cane,Michael Chvanov,Muhammad A. Javed,Victoria Elliott,Jane A Armstrong,Hayley Dingsdale,Nicole Cash,Yan Li,William Greenhalf,Rajarshi Mukherjee,Bhupendra S. Kaphalia,Mohammed Jaffar,Ole H. Petersen,Alexei V. Tepikin,Robert Sutton,David N. Criddle +17 more
TL;DR: The in vitro and in vivo damage was markedly inhibited by blockade of CEL, indicating the potential for development of specific therapy for treatment of alcoholic AP via inhibition of FAEE generation.