M
Michael Chvanov
Researcher at University of Liverpool
Publications - 35
Citations - 1826
Michael Chvanov is an academic researcher from University of Liverpool. The author has contributed to research in topics: Acinar cell & Mitochondrial permeability transition pore. The author has an hindex of 17, co-authored 33 publications receiving 1552 citations. Previous affiliations of Michael Chvanov include Royal Liverpool and Broadgreen University Hospital NHS Trust & Royal Liverpool University Hospital.
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Journal ArticleDOI
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.
Dabid N. Criddle,Stuart Gillies,Heidi K. Baumgartner-Wilson,Mohammed Jaffar,Mohammed Jaffar,E Chinje,Sarah Passmore,Michael Chvanov,Stephanie L. Barrow,Oleg Vsevolodovich Gerasimenko,Alexei V. Tepikin,Robert Sutton,Ole H. Petersen +12 more
TL;DR: It is suggested that acute generation of ROS by menadione occurs via redox cycling, the net effect of which is induction of apoptotic pancreatic acinar cell death.
Journal ArticleDOI
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Rajarshi Mukherjee,Rajarshi Mukherjee,Olga A. Mareninova,Irina V. Odinokova,Irina V. Odinokova,Wei Huang,Wei Huang,Wei Huang,J. A. Murphy,J. A. Murphy,Michael Chvanov,Michael Chvanov,Muhammad A. Javed,Muhammad A. Javed,Li Wen,Li Wen,David Booth,David Booth,Matthew C Cane,Muhammad Awais,Muhammad Awais,Bruno Gavillet,Rebecca M. Pruss,Sophie Schaller,Jeffery D. Molkentin,Alexei V. Tepikin,Alexei V. Tepikin,Ole H. Petersen,Stephen J. Pandol,Ilya Gukovsky,David N. Criddle,David N. Criddle,Anna S. Gukovskaya,Robert Sutton,Robert Sutton +34 more
TL;DR: The mechanism and consequences of MPTP opening are demonstrated to be fundamental to multiple forms of acute pancreatitis and validates the MPTP as a drug target for this disease.
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Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.
Li Wen,Svetlana Voronina,Muhammad A. Javed,Muhammad Awais,Peter Szatmary,Peter Szatmary,Diane Latawiec,Michael Chvanov,D. Collier,Wei Huang,John Barrett,Malcolm Begg,Kenneth A. Stauderman,Jack Roos,Sergey Grigoryev,Stephanie Ramos,Evan Rogers,Jeff Whitten,Gonul Velicelebi,Michael Dunn,Alexei V. Tepikin,David N. Criddle,Robert Sutton +22 more
TL;DR: Cytosolic calcium overload, mediated via ORAI1, contributes to the pathogenesis of acute pancreatitis.
Journal ArticleDOI
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
Ciara M. Walsh,Michael Chvanov,Lee P. Haynes,Ole H. Petersen,Alexei V. Tepikin,Robert D. Burgoyne +5 more
TL;DR: The idea that phosphoinositides are not essential but contribute toSTIM1 accumulation at ER–PM junctions with a second translocation mechanism involving direct STIM1–Orai interactions is supported.
Journal ArticleDOI
Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells
J. A. Murphy,David N. Criddle,Mark W. Sherwood,Michael Chvanov,Rajarshi Mukherjee,Euan McLaughlin,David Booth,Julia Vladimirovna Gerasimenko,Michael Raraty,Paula Ghaneh,John P. Neoptolemos,Oleg Vsevolodovich Gerasimenko,Alexei V. Tepikin,Gary M. Green,Joseph R. Reeve,Joseph R. Reeve,Ole H. Petersen,Robert Sutton +17 more
TL;DR: CCK at physiologic concentrations in the presence of atropine and tetrodotoxin elicits cytosolic Ca(2+) signaling, activates mitochondrial function, and stimulates enzyme secretion in isolated human pancreatic acinar cells, concluding that CCK acts directly on acinar Cells in the human pancreas.