T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.
TLDR
It is proposed that T CR signaling is sustained by stabilized microclusters and is terminated in the cSMAC, a structure from which TCR are sorted for degradation, and a role for F-actin in TCR signaling beyond microcluster formation is revealed.About:
This article is published in Immunity.The article was published on 2006-07-01 and is currently open access. It has received 828 citations till now. The article focuses on the topics: T-cell receptor & Immunological synapse formation.read more
Citations
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Journal ArticleDOI
T cell activation.
TL;DR: This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR), with a description of the current state of the understanding of TCR signaling and a summary of recent findings.
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Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
María Mittelbrunn,Cristina Gutiérrez-Vázquez,Carolina Villarroya-Beltri,Susana González,Fátima Sánchez-Cabo,Manuel A. González,Antonio Bernad,Francisco Sánchez-Madrid +7 more
TL;DR: It is shown that exosomes of T, B and dendritic immune cells contain microRNA (miRNA) repertoires that differ from those of their parent cells, and that miRNAs transferred during immune synapsis are able to modulate gene expression in recipient cells.
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Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Xiaolei Su,Jonathon A. Ditlev,Jonathon A. Ditlev,Enfu Hui,Enfu Hui,Wenmin Xing,Wenmin Xing,Sudeep Banjade,Sudeep Banjade,Julia Okrut,Julia Okrut,David S. King,Jack Taunton,Jack Taunton,Michael K. Rosen,Michael K. Rosen,Ronald D. Vale,Ronald D. Vale +18 more
TL;DR: It is demonstrated that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling and promote signaling outputs both in vitro and in human Jurkat T cells.
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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka,Masako Takamatsu,Wakana Kobayashi-Imanishi,Akiko Hashimoto-Tane,Miyuki Azuma,Takashi Saito +5 more
TL;DR: After encounter with its ligand, PD-1 translocates into TCR microclusters, where it transiently recruits SHP2 and suppresses phosphorylation of TCR signaling components and TCR-driven stop signals.
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CD28 and CTLA-4 coreceptor expression and signal transduction.
TL;DR: The current knowledge of the CD28 and CTLA‐4 signaling mechanisms [involving phosphatidylinositol 3 kinase (PI3K), growth factor receptor‐bound protein 2 (Grb2), Filamin A, protein kinase C θ (PKCθ), and phosphatases] that control T‐cell immunity are outlined.
References
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Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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Three-dimensional segregation of supramolecular activation clusters in T cells
TL;DR: The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
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The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells
TL;DR: The findings explain in quantitative terms the essential requirement for professional APCs in T cell priming and show that the duration of antigenic stimulation is the major factor determining the fate of naive and effector T cells.
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Direct observation of ligand recognition by T cells
TL;DR: It is shown that T cells expressing the CD4 antigen respond with transient calcium signalling to even a single agonist peptide–MHC ligand, and that the organization of molecules in the contact zone of the T cell and APC takes on the characteristics of an immunological synapse when only about ten agonists are present.