R
Rajesh Mikkilineni
Researcher at Takeda Pharmaceutical Company
Publications - 3
Citations - 352
Rajesh Mikkilineni is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Biobank & Exome. The author has an hindex of 2, co-authored 2 publications receiving 75 citations.
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Journal ArticleDOI
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Joseph D. Szustakowski,Suganthi Balasubramanian,Erika Kvikstad,Shareef Khalid,Paola G. Bronson,Ariella Sasson,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeffrey F. Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard J. Jacob,Sándor Szalma,Heiko Runz,Gregory Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: The UK Biobank Exome Sequencing Consortium (UKB-ESC) as mentioned in this paper is a private-public partnership between the UK Biopartition and eight biopharmaceutical companies that will complete the sequencing of exomes for all ~500,000 UKB participants.
Posted ContentDOI
Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank
Joseph D. Szustakowski,Suganthi Balasubramanian,Ariella Sasson,Shareef Khalid,Paola G. Bronson,Erika Kvikstad,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeff Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard Jacob,Sándor Szalma,Heiko Runz,Greg Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: Early results from the exome sequence data generated by the UKB-ESC for the first ~200,000 UKB subjects are described and the rationale for the use of human genetics in drug discovery as well as lessons learned are described.
Posted ContentDOI
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
Benjamin B. Sun,Joshua Chiou,Matthew Traylor,Christian Benner,Yi-Hsiang Hsu,Tom G. Richardson,Praveen Surendran,Anubha Mahajan,Chloe Robins,Steven G. Vasquez-Grinnell,Liping Hou,Erika Kvikstad,Oliver S. Burren,Madeleine Cule,Jonathan Davitte,Kyle Ferber,Christopher E. Gillies,Åsa K. Hedman,Sile Hu,Tinchi Lin,Rajesh Mikkilineni,R. Pendergrass,Corran Pickering,Bram Prins,Anil Raj,Jamie Robinson,Anurag Sethi,Lucas D. Ward,Samantha Welsh,Carissa M. Willis,Lucy Burkitt-Gray,Mary Helen Black,Eric B. Fauman,Joanna M. M. Howson,Hyun Min Kang,Mark I. McCarthy,Eugene Melamud,Paul Nioi,Slavé Petrovski,Robert A. Scott,Erin N. Smith,Sándor Szalma,Dawn M. Waterworth,Lyndon J. Mitnaul,Joseph D. Szustakowski,Bradford W. Gibson,Melissa R. Miller,Christopher W. Whelan +47 more
TL;DR: The study provides an updated characterisation of the genetic architecture of the plasma proteome, leveraging population-scale proteomics to provide novel, extensive insights into trans pQTLs across multiple biological domains.