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Lyndon J. Mitnaul
Researcher at Regeneron
Publications - 8
Citations - 1260
Lyndon J. Mitnaul is an academic researcher from Regeneron. The author has contributed to research in topics: Exome & Exome sequencing. The author has an hindex of 6, co-authored 8 publications receiving 516 citations. Previous affiliations of Lyndon J. Mitnaul include University Medical Center Groningen.
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Journal ArticleDOI
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
Frederick E. Dewey,Michael F. Murray,John D. Overton,Lukas Habegger,Joseph B. Leader,Samantha N. Fetterolf,Colm O'Dushlaine,Cristopher V. Van Hout,Jeffrey Staples,Claudia Gonzaga-Jauregui,Raghu Metpally,Sarah A. Pendergrass,Monica A. Giovanni,H. Lester Kirchner,Suganthi Balasubramanian,Noura S. Abul-Husn,Dustin N. Hartzel,Daniel R. Lavage,Korey A. Kost,Jonathan S. Packer,Alexander Lopez,John Penn,Semanti Mukherjee,Nehal Gosalia,Manoj Kanagaraj,Alexander H. Li,Lyndon J. Mitnaul,Lance J. Adams,Thomas N. Person,Kavita Praveen,Anthony Marcketta,Matthew S. Lebo,Christina Austin-Tse,Heather Mason-Suares,Shannon Bruse,Scott Mellis,Robert H. Phillips,Neil Stahl,Andrew J. Murphy,Aris N. Economides,Kimberly A. Skelding,Christopher D. Still,James R. Elmore,Ingrid B. Borecki,George D. Yancopoulos,F. Daniel Davis,William A. Faucett,Omri Gottesman,Marylyn D. Ritchie,Alan R. Shuldiner,Jeffrey G. Reid,David H. Ledbetter,Aris Baras,David J. Carey +53 more
TL;DR: Exome-wide association analyses of EHR-derived lipid values, newly implicating rare predicted LoFs, and deleterious missense variants in G6PC in association with triglyceride levels found associations supporting the majority of therapeutic targets for lipid lowering.
Journal ArticleDOI
Exome sequencing and analysis of 454,787 UK Biobank participants.
Joshua D. Backman,Alexander H. Li,Anthony Marcketta,Dylan Sun,Joelle Mbatchou,Michael D. Kessler,Christian Benner,Daren Liu,Adam E. Locke,Suganthi Balasubramanian,Ashish Yadav,Nilanjana Banerjee,Christopher E. Gillies,Amy Damask,Simon Liu,Xiaodong Bai,Alicia Hawes,Evan Maxwell,Lauren Gurski,Kyoko Watanabe,Jack A. Kosmicki,Veera M. Rajagopal,Jason Mighty,Marcus B. Jones,Lyndon J. Mitnaul,Eli A. Stahl,Giovanni Coppola,Eric Jorgenson,Lukas Habegger,William J Salerno,Alan R. Shuldiner,Luca A. Lotta,John D. Overton,Michael N. Cantor,Jeffrey G. Reid,George D. Yancopoulos,Hyun Min Kang,Jonathan Marchini,Aris Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira +40 more
TL;DR: This paper used exome sequencing to explore protein altering variants and their consequences in 454,787 UK Biobank study participants and identified 12 million coding variants, including ~1 million loss-of-function and ~1.8 million deleterious missense variants.
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,Gardar Sveinbjornsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Michael Morley,Mark Chaffin,Anna Helgadottir,Niek Verweij,Abbas Dehghan,Peter Almgren,Charlotte Andersson,Krishna G. Aragam,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeffrey Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xing Chen,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Doerr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,Tõnu Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daniel F. Gudbjartsson,Rebecca Gutmann,Christopher M. Haggerty,Pim van der Harst,Craig L. Hyde,Erik Ingelsson,J. Wouter Jukema,Maryam Kavousi,Kay-Tee Khaw,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrik K. E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,Winfried Maerz,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Colin N. A. Palmer,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Simon P. R. Romaine,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,Jessica van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Mari-Liis Tammesoo,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,Abirami Veluchamy,Uwe Voelker,Adriaan A. Voors,Xiaosong Wang,Nicholas J. Wareham,Dawn M. Waterworth,Peter Weeke,Raul Weiss,Kerri L. Wiggins,Heming Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,John J.V. McMurray,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,J. Gustav Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. Thomas Lumbers,Gonçalo R. Abecasis,Joshua D. Backman,Xiaodong Bai,Suganthi Balasubramanian,Nilanjana Banerjee,Aris Baras,Leland Barnard,Christina Beechert,Andrew Blumenfeld,Michael N. Cantor,Yating Chai,Giovanni Coppola,Amy Damask,Frederick E. Dewey,Aris N. Economides,Gisu Eom,Caitlin Forsythe,Erin D. Fuller,Zhenhua Gu,Lauren Gurski,Paloma M. Guzzardo,Lukas Habegger,Young Hahn,Alicia Hawes,Cristopher V. Van Hout,Marcus B. Jones,Shareef Khalid,Michael Lattari,Alexander H. Li,Nan Lin,Daren Liu,Alexander Lopez,Kia Manoochehri,Jonathan Marchini,Anthony Marcketta,Evan Maxwell,Shane A. McCarthy,Lyndon J. Mitnaul,Colm O'Dushlaine,John D. Overton,Maria Sotiropoulos Padilla,Charles Paulding,John Penn,Manasi Pradhan,Jeffrey G. Reid,Thomas D. Schleicher,Claudia Schurmann,Alan R. Shuldiner,Jeffrey Staples,Dylan Sun,Karina Toledo,Ricardo H. Ulloa,Louis Widom,Sarah E. Wolf,Ashish Yadav,Bin Ye +201 more
TL;DR: In this paper, the authors report results from a genome-wide association studies (GWAS) meta-analysis of heart failure comprising 47,309 cases and 930,014 controls.
Journal ArticleDOI
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Joseph D. Szustakowski,Suganthi Balasubramanian,Erika Kvikstad,Shareef Khalid,Paola G. Bronson,Ariella Sasson,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeffrey F. Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard J. Jacob,Sándor Szalma,Heiko Runz,Gregory Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: The UK Biobank Exome Sequencing Consortium (UKB-ESC) as mentioned in this paper is a private-public partnership between the UK Biopartition and eight biopharmaceutical companies that will complete the sequencing of exomes for all ~500,000 UKB participants.
Posted ContentDOI
Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank
Joseph D. Szustakowski,Suganthi Balasubramanian,Ariella Sasson,Shareef Khalid,Paola G. Bronson,Erika Kvikstad,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeff Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard Jacob,Sándor Szalma,Heiko Runz,Greg Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: Early results from the exome sequence data generated by the UKB-ESC for the first ~200,000 UKB subjects are described and the rationale for the use of human genetics in drug discovery as well as lessons learned are described.