J
Joshua Chiou
Researcher at University of California, San Diego
Publications - 48
Citations - 2238
Joshua Chiou is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 17, co-authored 39 publications receiving 1108 citations. Previous affiliations of Joshua Chiou include University of California, Berkeley & University of California, Los Angeles.
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Journal ArticleDOI
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Miriam S. Udler,Jaegil Kim,Marcin von Grotthuss,Sílvia Bonàs-Guarch,Joanne B. Cole,Joanne B. Cole,Joshua Chiou,Michael Boehnke,Markku Laakso,Markku Laakso,Gil Atzmon,Benjamin Glaser,Josep M. Mercader,Kyle J. Gaulton,Kyle J. Gaulton,Jason Flannick,Gad Getz,Jose C. Florez +17 more
TL;DR: The approach identifies salient T2D genetically anchored and physiologically informed pathways, and supports the use of genetics to deconstruct T1D heterogeneity.
Posted ContentDOI
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Pascal Barbry,Christoph Muus,Christoph Muus,Malte D Luecken,Gökcen Eraslan,Avinash Waghray,Graham Heimberg,Lisa Sikkema,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smilie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,J. Samuel,Allon Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Marie Deprez,David Fischer,Astrid Gillich,Joshua Gould,Minzhe Guo,Austin J. Gutierrez,Arun C. Habermann,Tyler Harvey,Peng He,Xiaomeng Hou,Xiaomeng Hou,Lijuan Hu,Alok Jaiswal,Peiyong Jiang,Theodoros Kapellos,Christin S. Kuo,Ludvig Larsson,Michael Leney-Greene,Kyungtae Lim,Monika Litviňuková,Monika Litviňuková,Ji Lu,Leif S. Ludwig,Wendy Luo,Henrike Maatz,Elo Madissoon,Lira Mamanova,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Charles-Hugo Marquette,Ian Mbano,Alexi McAdams,Ross J. Metzger,Ahmad N. Nabhan,Sarah K. Nyquist,Lolita Penland,Olivier Poirion,Sergio Poli,Cancan Qi,Rachel Queen,Daniel Reichart,Daniel Reichart,Ivan O. Rosas,Jonas C. Schupp,Rahul Sinha,Rene Sit,Kamil Slowikowski,Kamil Slowikowski,Michal Slyper,Neal Smith,Neal Smith,Alex Sountoulidis,Maximilian Strunz,Dawei Sun,Carlos Talavera-López,Peng Tan,Jessica Tantivit,Jessica Tantivit,Kyle J. Travaglini,Nathan R. Tucker,Katherine A. Vernon,Katherine A. Vernon,Marc Wadsworth,Julia Waldman,Xiuting Wang,Wenjun Yan,William Zhao,Carly Ziegler +113 more
TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.
Journal ArticleDOI
An atlas of dynamic chromatin landscapes in mouse fetal development
David U. Gorkin,David U. Gorkin,Iros Barozzi,Iros Barozzi,Yuan Zhao,Yuan Zhao,Yanxiao Zhang,Hui Huang,Hui Huang,Ah Young Lee,Bin Li,Joshua Chiou,Andre Wildberg,Bo Ding,Bo Zhang,Mengchi Wang,J. Seth Strattan,Jean M. Davidson,Yunjiang Qiu,Yunjiang Qiu,Veena Afzal,Jennifer A. Akiyama,Ingrid Plajzer-Frick,Catherine S. Novak,Momoe Kato,Tyler H. Garvin,Quan T. Pham,Anne N. Harrington,Brandon J. Mannion,Elizabeth Lee,Yoko Fukuda-Yuzawa,Yupeng He,Yupeng He,Sebastian Preissl,Sebastian Preissl,Sora Chee,Jee Yun Han,Brian A. Williams,Diane Trout,Henry Amrhein,Hongbo Yang,J. Michael Cherry,Wei Wang,Kyle J. Gaulton,Joseph R. Ecker,Yin Shen,Diane E. Dickel,Axel Visel,Axel Visel,Axel Visel,Len A. Pennacchio,Len A. Pennacchio,Len A. Pennacchio,Bing Ren +53 more
TL;DR: Analysis of chromatin state and accessibility in mouse tissues from twelve sites and eight developmental stages provides the most comprehensive view of Chromatin dynamics to date.
Journal ArticleDOI
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Christoph Muus,Malte D Luecken,Gökcen Eraslan,Lisa Sikkema,Avinash Waghray,Graham Heimberg,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smillie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,Samuel J. Allon,Samuel J. Allon,Samuel J. Allon,Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Steven Callori,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Anna S E Cuomo,Marie Deprez,Grant Duclos,Denise Fine,David S. Fischer,Shila Ghazanfar,Astrid Gillich +53 more
TL;DR: In this paper, cell-type-specific expression of ACE2, TMPRSS2 and CTSL across 107 single-cell RNA-sequencing studies from different tissues was assessed.
Journal ArticleDOI
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.
Allen Wang,Joshua Chiou,Olivier Poirion,Justin Buchanan,Michael J Valdez,Jamie M. Verheyden,Xiaomeng Hou,Parul Kudtarkar,Sharvari Narendra,Jacklyn M Newsome,Minzhe Guo,Minzhe Guo,Dina A. Faddah,Kai Zhang,Randee E. Young,Randee E. Young,Justinn Barr,Eniko Sajti,Ravi S. Misra,Heidie Huyck,Lisa Rogers,Cory Poole,JA Whitsett,JA Whitsett,Gloria S. Pryhuber,Yan Xu,Yan Xu,Kyle J. Gaulton,Sebastian Preissl,Xin Sun +29 more
TL;DR: These datasets will facilitate interpretation of risk loci for lung diseases and provide insight into regulatory logic underlying genes implicated in COVID-19 in individual lung cell types across age.