M
Mehmet Eren Ahsen
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 67
Citations - 1763
Mehmet Eren Ahsen is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Gene regulatory network & Compressed sensing. The author has an hindex of 16, co-authored 65 publications receiving 1017 citations. Previous affiliations of Mehmet Eren Ahsen include Mount Sinai Health System & University of Texas at Dallas.
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Journal ArticleDOI
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Michael P. Menden,Michael P. Menden,Dennis Wang,Dennis Wang,Michael Mason,Bence Szalai,Bence Szalai,Bence Szalai,Krishna C. Bulusu,Yuanfang Guan,Thomas Yu,Jaewoo Kang,Minji Jeon,Russell D. Wolfinger,Tin Nguyen,Mikhail Zaslavskiy,In Sock Jang,Zara Ghazoui,Mehmet Eren Ahsen,Robert Vogel,Elias Chaibub Neto,Thea Norman,Eric Tang,Mathew J. Garnett,Giovanni Y. Di Veroli,Stephen Fawell,Gustavo Stolovitzky,Gustavo Stolovitzky,Justin Guinney,Jonathan R. Dry,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Julio Saez-Rodriguez +32 more
TL;DR: A large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers are reported.
Journal ArticleDOI
Intratumoral heterogeneity and clonal evolution in liver cancer.
Bojan Losic,Amanda J. Craig,Carlos Villacorta-Martin,Sebastiao N. Martins-Filho,Sebastiao N. Martins-Filho,Nicholas K. Akers,Xintong Chen,Mehmet Eren Ahsen,Johann von Felden,Johann von Felden,Ismail Labgaa,Ismail Labgaa,Delia DʹAvola,Delia DʹAvola,Kimaada Allette,Sergio A. Lira,Glaucia C. Furtado,Teresa Garcia-Lezana,Paula Restrepo,Ashley Stueck,Stephen C. Ward,Maria Isabel Fiel,Spiros P. Hiotis,Ganesh Gunasekaran,Daniela Sia,Eric E. Schadt,Eric E. Schadt,Robert Sebra,Robert Sebra,Myron Schwartz,Josep M. Llovet,Josep M. Llovet,Josep M. Llovet,Swan N. Thung,Gustavo Stolovitzky,Gustavo Stolovitzky,Augusto Villanueva +36 more
TL;DR: In hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.
Journal ArticleDOI
Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms
Thomas Schaffter,Diana S. M. Buist,Christoph I. Lee,Yaroslav Nikulin,Dezső Ribli,Yuanfang Guan,William Lotter,Zequn Jie,Hao Du,Sijia Wang,Jiashi Feng,Mengling Feng,Hyo-Eun Kim,F. Albiol,Alberto Albiol,Stephen Morrell,Zbigniew Wojna,Mehmet Eren Ahsen,Umar Asif,Antonio Jimeno Yepes,Shivanthan A.C. Yohanandan,Simona Rabinovici-Cohen,Darvin Yi,Bruce Hoff,Thomas Yu,Elias Chaibub Neto,Daniel L. Rubin,Peter Lindholm,Laurie R. Margolies,Russell B. McBride,Joseph H. Rothstein,Weiva Sieh,Rami Ben-Ari,Stefan Harrer,Andrew D. Trister,Stephen H. Friend,Thea Norman,Berkman Sahiner,Fredrik Strand,Fredrik Strand,Justin Guinney,Gustavo Stolovitzky,Lester Mackey,Joyce Cahoon,Li Shen,Jae Ho Sohn,Hari Trivedi,Yiqiu Shen,Ljubomir Buturovic,Jose Costa Pereira,Jaime S. Cardoso,Eduardo Castro,Karl Trygve Kalleberg,Obioma Pelka,Imane Nedjar,Krzysztof J. Geras,Felix Nensa,Ethan Goan,Sven Koitka,Sven Koitka,Luis Caballero,David D. Cox,Pavitra Krishnaswamy,Gaurav Pandey,Christoph M. Friedrich,Dimitri Perrin,Clinton Fookes,Bibo Shi,Gerard Cardoso Negrie,Michael Kawczynski,Kyunghyun Cho,Can Son Khoo,Joseph Y. Lo,A. Gregory Sorensen,Hwejin Jung +74 more
TL;DR: This diagnostic accuracy study evaluates whether artificial intelligence can overcome human mammography interpretation limits with a rigorous, unbiased evaluation of machine learning algorithms.
Journal ArticleDOI
exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids
Oscar Murillo,William Thistlethwaite,Joel Rozowsky,Sai Lakshmi Subramanian,Rocco Lucero,Neethu Shah,Andrew R. Jackson,Srimeenakshi Srinivasan,Allen Chung,Allen Chung,Clara D. Laurent,Robert R. Kitchen,Timur R. Galeev,Jonathan Warrell,James A. Diao,James A. Diao,Joshua A. Welsh,Kristina Hanspers,Anders Riutta,Sebastian Burgstaller-Muehlbacher,Ravi V. Shah,Ashish Yeri,Lisa M. Miller Jenkins,Mehmet Eren Ahsen,Carlos Cordon-Cardo,Navneet Dogra,Navneet Dogra,Stacey M. Gifford,Joshua T. Smith,Gustavo Stolovitzky,Gustavo Stolovitzky,Ashutosh K. Tewari,Benjamin H. Wunsch,Kamlesh K Yadav,Kirsty Danielson,Justyna Filant,Courtney Moeller,Parham Nejad,Anu Paul,Bridget Simonson,David K. Wong,David K. Wong,Xuan Zhang,Leonora Balaj,Roopali Gandhi,Anil K. Sood,Roger P. Alexander,Liang Wang,Chunlei Wu,David T.W. Wong,David J. Galas,Kendall Van Keuren-Jensen,Tushar Patel,Jennifer Jones,Saumya Das,Kei-Hoi Cheung,Alexander R. Pico,Andrew I. Su,Robert L. Raffai,Robert L. Raffai,Louise C. Laurent,Matthew E. Roth,Mark Gerstein,Aleksandar Milosavljevic +63 more
TL;DR: A model with six exRNA cargo types, each detectable in multiple biofluids, is presented and tools for deconvolution and analysis of user-provided case-control studies are provided to enable wide application of this model.
Journal ArticleDOI
Assessment of network module identification across complex diseases.
Sarvenaz Choobdar,Mehmet Eren Ahsen,Jake Crawford,Mattia Tomasoni,Mattia Tomasoni,Tao Fang,David Lamparter,David Lamparter,Junyuan Lin,Benjamin Hescott,Xiaozhe Hu,Johnathan Mercer,Ted Natoli,Rajiv Narayan,Aravind Subramanian,Jitao D. Zhang,Gustavo Stolovitzky,Gustavo Stolovitzky,Zoltán Kutalik,Kasper Lage,Kasper Lage,Kasper Lage,Donna K. Slonim,Julio Saez-Rodriguez,Lenore J. Cowen,Sven Bergmann,Sven Bergmann,Sven Bergmann,Daniel Marbach,Daniel Marbach,Daniel Marbach +30 more
TL;DR: This community challenge establishes biologically interpretable benchmarks, tools and guidelines for molecular network analysis to study human disease biology and finds that most of these modules correspond to core disease-relevant pathways, which often comprise therapeutic targets.