M
Maria Novatchkova
Researcher at Austrian Academy of Sciences
Publications - 38
Citations - 3922
Maria Novatchkova is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Heterochromatin & Piwi-interacting RNA. The author has an hindex of 23, co-authored 38 publications receiving 3166 citations. Previous affiliations of Maria Novatchkova include Research Institute of Molecular Pathology.
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Journal ArticleDOI
Human blood vessel organoids as a model of diabetic vasculopathy
Reiner A. Wimmer,Alexandra Leopoldi,Martin Aichinger,Nikolaus Wick,Brigitte Hantusch,Maria Novatchkova,Jasmin Taubenschmid,Monika Hämmerle,Christopher Esk,Joshua A. Bagley,Dominik Lindenhofer,Guibin Chen,Manfred Boehm,Chukwuma A. Agu,Fengtang Yang,Beiyuan Fu,Johannes Zuber,Juergen A. Knoblich,Dontscho Kerjaschki,Josef M. Penninger,Josef M. Penninger +20 more
TL;DR: Self-organizing three-dimensional human blood vessel organoids derived from human stem cells recapitulate the structure and function of human blood vessels and are amenable systems for modelling and identifying the regulators of diabetic vasculopathy, a disease that affects hundreds of millions of patients worldwide.
Journal ArticleDOI
A dual role for autophagy in a murine model of lung cancer
Shuan Rao,Luigi Tortola,Thomas Perlot,Gerald Wirnsberger,Maria Novatchkova,Roberto Nitsch,Peter Sykacek,Lukas Frank,Daniel Schramek,Vukoslav Komnenovic,Verena Sigl,Karin Aumayr,Gerald Schmauss,Nicole Fellner,Stephan Handschuh,Martin Glösmann,Pawel Pasierbek,Michaela Schlederer,Guenter P. Resch,Yuting Ma,Yuting Ma,Yuting Ma,Heng Yang,Heng Yang,Heng Yang,Helmuth Popper,Lukas Kenner,Guido Kroemer,Josef M. Penninger +28 more
TL;DR: Tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage of tumour-bearing mice, suggesting a link between deregulated autophagy and regulatory T cell controlled anticancer immunity.
Journal ArticleDOI
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
Jennifer L. Mummery-Widmer,Masakazu Yamazaki,Masakazu Yamazaki,Thomas Stoeger,Maria Novatchkova,Maria Novatchkova,Sheetal Bhalerao,Sheetal Bhalerao,Doris Chen,Georg Dietzl,Barry J. Dickson,Juergen A. Knoblich +11 more
TL;DR: The use of a library of Drosophila strains expressing inducible hairpin RNAi constructs to study the Notch signalling pathway during external sensory organ development is reported, showing that complex developmental processes can be analysed on a genome-wide level and provide a unique resource for functional annotation of the Drosophile genome.
Journal ArticleDOI
Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst,Weihua Zhang,Irene Mateo Leach,Augusto Rendon,Niek Verweij,Joban Sehmi,Dirk S. Paul,Ulrich Elling,Hooman Allayee,Xinzhong Li,Aparna Radhakrishnan,Sian Tsung Tan,Katrin Voss,Christian X. Weichenberger,Cornelis A. Albers,Abtehale Al-Hussani,Folkert W. Asselbergs,Marina Ciullo,Fabrice Danjou,Christian Dina,Tõnu Esko,David M. Evans,Lude Franke,Martin Gögele,Jaana Hartiala,Micha Hersch,Hilma Holm,Jouke-Jan Hottenga,Stavroula Kanoni,Marcus E. Kleber,Vasiliki Lagou,Claudia Langenberg,Lorna M. Lopez,Leo-Pekka Lyytikäinen,Olle Melander,Federico Murgia,Ilja M. Nolte,Paul F. O'Reilly,Sandosh Padmanabhan,Afshin Parsa,Nicola Pirastu,Eleonora Porcu,Laura Portas,Inga Prokopenko,Janina S. Ried,So-Youn Shin,Clara S. Tang,Alexander Teumer,Michela Traglia,Sheila Ulivi,Harm-Jan Westra,Jian Yang,Jing Hua Zhao,Franco Anni,Abdel Abdellaoui,Antony P. Attwood,Beverley Balkau,Stefania Bandinelli,François Bastardot,Beben Benyamin,Bernhard O. Boehm,William O.C.M. Cookson,Debashish Das,Paul I.W. de Bakker,Rudolf A. de Boer,Eco J. C. de Geus,Marleen H. M. de Moor,Maria Dimitriou,Francisco S. Domingues,Angela Döring,Gunnar Engström,Gudmundur I. Eyjolfsson,Luigi Ferrucci,Krista Fischer,Renzo Galanello,Stephen F. Garner,Bernd Genser,Quince Gibson,Giorgia Girotto,Daniel F. Gudbjartsson,Sarah E. Harris,Anna-Liisa Hartikainen,Claire E. Hastie,Bo Hedblad,Thomas Illig,Jennifer Jolley,Mika Kähönen,Ido P. Kema,John P. Kemp,Liming Liang,Heather Lloyd-Jones,Ruth J. F. Loos,Stuart Meacham,Sarah E. Medland,Christa Meisinger,Yasin Memari,Evelin Mihailov,Kathy Miller,Miriam F. Moffatt,Matthias Nauck,Maria Novatchkova,Teresa Nutile,Isleifur Olafsson,Pall T. Onundarson,Debora Parracciani,Brenda W.J.H. Penninx,Lucia Perseu,Antonio Piga,Giorgio Pistis,Anneli Pouta,Ursula Puc,Olli T. Raitakari,Susan M. Ring,Antonietta Robino,Daniela Ruggiero,Aimo Ruokonen,Aude Saint-Pierre,Cinzia Sala,Andres Salumets,Jennifer G. Sambrook,Hein Schepers,Carsten Oliver Schmidt,Herman H W Silljé,Robert Sladek,Johannes H. Smit,John M. Starr,Jonathan Stephens,Patrick Sulem,Toshiko Tanaka,Unnur Thorsteinsdottir,Vinicius Tragante,Wiek H. van Gilst,L. Joost van Pelt,Dirk J. van Veldhuisen,Uwe Völker,John Whitfield,Gonneke Willemsen,Bernhard R. Winkelmann,Gerald Wirnsberger,Ale Algra,Francesco Cucca,Adamo Pio D'Adamo,John Danesh,Ian J. Deary,Anna F. Dominiczak,Paul Elliott,Paolo Fortina,Philippe Froguel,Paolo Gasparini,Andreas Greinacher,Stanley L. Hazen,Marjo-Riitta Järvelin,Kay-Tee Khaw,Terho Lehtimäki,Winfried Maerz,Nicholas G. Martin,Andres Metspalu,Braxton D. Mitchell,Grant W. Montgomery,Carmel Moore,Gerjan Navis,Mario Pirastu,Peter P. Pramstaller,Ramiro Ramirez-Solis,Eric E. Schadt,James Scott,Alan R. Shuldiner,George Davey Smith,J. Gustav Smith,Harold Snieder,Rossella Sorice,Tim D. Spector,Kari Stefansson,Michael Stumvoll,W.H. Wilson Tang,Daniela Toniolo,Anke Tönjes,Peter M. Visscher,Peter Vollenweider,Nicholas J. Wareham,Bruce H. R. Wolffenbuttel,Dorret I. Boomsma,Jacques S. Beckmann,George Dedoussis,Panos Deloukas,Manuel A. R. Ferreira,Serena Sanna,Manuela Uda,Andrew A. Hicks,Josef M. Penninger,Christian Gieger,Jaspal S. Kooner,Willem H. Ouwehand,Nicole Soranzo,John C. Chambers +194 more
TL;DR: A genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals identifies 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4–9% of the phenotypic variance per trait.
Journal ArticleDOI
The Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division
Sarah K. Bowman,Ralph A. Neumüller,Maria Novatchkova,Maria Novatchkova,Quansheng Du,Juergen A. Knoblich +5 more
TL;DR: The data suggest a model in which asymmetrically localized Pins-G alphai complexes regulate spindle orientation by directly binding to Mud, the Drosophila homolog of NuMA, which can bind to microtubules and enhance microtubule polymerization.