R
Randall Espinoza
Researcher at University of California, Los Angeles
Publications - 89
Citations - 2540
Randall Espinoza is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Electroconvulsive therapy & Medicine. The author has an hindex of 23, co-authored 68 publications receiving 1758 citations. Previous affiliations of Randall Espinoza include University of California & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial
Paul E. Holtzheimer,Mustafa M. Husain,Mustafa M. Husain,Sarah H. Lisanby,Stephan F. Taylor,Louis A. Whitworth,Shawn M. McClintock,Shawn M. McClintock,Konstantin V. Slavin,Joshua A. Berman,Guy M. McKhann,Parag G. Patil,Barry R. Rittberg,Aviva Abosch,Ananda K. Pandurangi,Kathryn L. Holloway,Raymond W. Lam,Christopher R. Honey,Joseph S. Neimat,Jaimie M. Henderson,Charles DeBattista,Anthony J. Rothschild,Julie G. Pilitsis,Randall Espinoza,Georgios Petrides,Alon Y. Mogilner,Keith Matthews,De Lea Peichel,Robert E. Gross,Clement Hamani,Andres M. Lozano,Helen S. Mayberg +31 more
TL;DR: This study confirmed the safety and feasibility of subcallosal cingulate DBS as a treatment for treatment-resistant depression but did not show statistically significant antidepressant efficacy in a 6-month double-blind, sham-controlled trial.
Journal ArticleDOI
Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression.
Shantanu H. Joshi,Randall Espinoza,Tara Pirnia,Jie Shi,Yalin Wang,Brandon Ayers,Amber M. Leaver,Roger P. Woods,Katherine L. Narr +8 more
TL;DR: ECT-induced neuroplasticity in the hippocampus and amygdala relates to improved clinical response and is pronounced in regions with prominent connections to ventromedial prefrontal cortex and other limbic structures.
Journal ArticleDOI
Volume of the human Hippocampus and clinical response following Electroconvulsive Therapy
Leif Oltedal,Katherine L. Narr,Christopher C. Abbott,Amit Anand,Miklos Argyelan,Hauke Bartsch,Udo Dannlowski,Annemieke Dols,Philip van Eijndhoven,Louise Emsell,Vera Jane Erchinger,Randall Espinoza,Tim Hahn,Lars G. Hanson,Gerhard Hellemann,Martin Balslev Jørgensen,Ute Kessler,Mardien L. Oudega,Olaf B. Paulson,Ronny Redlich,Pascal Sienaert,M. L. Stek,Indira Tendolkar,Mathieu Vandenbulcke,Ketil J. Oedegaard,Anders M. Dale +25 more
TL;DR: The results suggest that the high efficacy of ECT is not explained by hippocampal enlargement, which alone might not serve as a viable biomarker for treatment outcome.
Journal ArticleDOI
Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression.
H Lyden,Randall Espinoza,Tara Pirnia,Kristi A. Clark,Shantanu H. Joshi,Amber M. Leaver,Roger P. Woods,Katherine L. Narr +7 more
TL;DR: Altered WM microstructure in pathways connecting frontal and limbic areas occur in MDD, are modulated by ECT and relate to therapeutic response, suggesting increased fiber integrity in dorsal fronto-limbic pathways involved in mood regulation.
Journal ArticleDOI
Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression.
Stephanie Njau,Shantanu H. Joshi,Randall Espinoza,Amber M. Leaver,Megha Vasavada,Antonio Marquina,Roger P. Woods,Katherine L. Narr +7 more
TL;DR: ECT elicits robust effects on brain chemistry, impacting Cre, NAA and Glx, which suggests restorative and neurotrophic processes, and lower NAA levels in the dACC at baseline predicted reductions in depressive symptoms.