R
Raphael Kopan
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 187
Citations - 30684
Raphael Kopan is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Notch signaling pathway & Notch proteins. The author has an hindex of 79, co-authored 187 publications receiving 28794 citations. Previous affiliations of Raphael Kopan include University of Illinois at Chicago & Tel Aviv University.
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Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
Journal ArticleDOI
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper,Wim Annaert,Philippe Cupers,Paul Saftig,Katleen Craessaerts,Jeff S. Mumm,Eric H. Schroeter,Vincent Schrijvers,Michael S. Wolfe,William J. Ray,Alison Goate,Raphael Kopan +11 more
TL;DR: It is reported that, in mammalian cells, PS1 deficiency also reduces the proteolytic release of NICD from a truncated Notch construct, thus identifying the specific biochemical step of the Notch signalling pathway that is affected by PS1.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Signalling downstream of activated mammalian Notch.
Sophie Jarriault,Christel Brou,Frédérique Logeat,Eric H. Schroeter,Raphael Kopan,Alain Israël +5 more
TL;DR: It is shown that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-JK and act as transcriptional activators through theKBF2-binding sites of the HES-1 promoter and block MyoD-induced myogenesis5-7.
Journal ArticleDOI
Notch Signaling: From the Outside In
Jeff S. Mumm,Raphael Kopan +1 more
TL;DR: The efforts of many roups that, over the past decade, contributed to the discovry that a novel signaling paradigm, Regulated Intramembrane Proteolysis (RIP), controls Notch receptor activation are summarized.