R
Raquel Carvalho Montenegro
Researcher at Federal University of Ceará
Publications - 138
Citations - 3255
Raquel Carvalho Montenegro is an academic researcher from Federal University of Ceará. The author has contributed to research in topics: Cancer & Cytotoxicity. The author has an hindex of 28, co-authored 123 publications receiving 2669 citations. Previous affiliations of Raquel Carvalho Montenegro include University of Oxford & Structural Genomics Consortium.
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Journal ArticleDOI
The Genomic Ancestry of Individuals from Different Geographical Regions of Brazil Is More Uniform Than Expected
Sérgio D.J. Pena,Giuliano Di Pietro,Mateus Fuchshuber-Moraes,Julia P. Genro,Mara H. Hutz,Fernanda S G Kehdy,Fabiana B. Kohlrausch,Luiz Alexandre V. Magno,Raquel Carvalho Montenegro,Manoel Odorico de Moraes,Maria Elisabete Amaral de Moraes,Milene Raiol de Moraes,Elida B. Ojopi,Jamila Alessandra Perini,Clarice Racciopi,Ândrea Ribeiro-dos-Santos,Fabrício Rios-Santos,Marco Aurélio Romano-Silva,Vinicius A. Sortica,Guilherme Suarez-Kurtz +19 more
TL;DR: It is proposed that the immigration of six million Europeans to Brazil in the 19th and 20th centuries is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories.
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Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.
Patrícia Marçal da Costa,Paulo Michel Pinheiro Ferreira,Vanderlan da Silva Bolzani,Maysa Furlan,Vânia Aparecida de Freitas Formenton Macedo dos Santos,Joaquim Corsino,Manoel Odorico de Moraes,Letícia V. Costa-Lotufo,Raquel Carvalho Montenegro,Cláudia Pessoa +9 more
TL;DR: The present data point to the importance of pristimerin as representative of an emerging class of potential anticancer chemicals, exhibiting an antiproliferative effect by inhibiting DNA synthesis and triggering apoptosis.
Journal ArticleDOI
MYC deregulation in gastric cancer and its clinicopathological implications.
Carolina Rosal Teixeira de Souza,Mariana Ferreira Leal,Danielle Queiroz Calcagno,Eliana Kelly Costa Sozinho,Bárbara do Nascimento Borges,Raquel Carvalho Montenegro,Ândrea Kely Campos Ribeiro dos Santos,Sidney Santos,Helem Ferreira Ribeiro,Paulo Pimentel Assumpção,Marília de Arruda Cardoso Smith,Rommel Rodríguez Burbano +11 more
TL;DR: MYC deregulation was mainly associated with poor prognostic features and also reinforced the presence of different pathways involved in intestinal-type and diffuse-type gastric carcinogenesis, suggesting that MYC may be a useful marker for clinical stratification and prognosis.
Journal ArticleDOI
MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer
Danielle Queiroz Calcagno,Danielle Queiroz Calcagno,Vanessa Morais Freitas,Mariana Ferreira Leal,Carolina Rosal Teixeira de Souza,Samia Demachki,Raquel Carvalho Montenegro,Paulo Pimentel Assumpção,André Salim Khayat,Marília de Arruda Cardoso Smith,Andrea Kelly Campos Ribeiro dos Santos,Rommel Rodríguez Burbano +11 more
TL;DR: FBXW7 and MYC mRNA may play a role in aggressive biologic behavior of gastric cancer cells and may be a useful indicator of poor prognosis and a candidate target for new therapies against Gastric cancer.
Journal ArticleDOI
Cytotoxic, Trypanocidal Activities and Physicochemical Parameters of nor-β-Lapachone-based 1,2,3-Triazoles
N Eufrânio,Maria Aline,B. F. de Moura,Antonio V. Pinto,Maria do Carmo,F. R. Pinto,Ana Jérsia Araújo,Cláudia Pessoa,Letícia V. Costa-Lotufo,Raquel Carvalho Montenegro,Vitor F. Ferreira,Marilia O. F. Goulart +11 more
TL;DR: In this article, the cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) and B-16 (murine melanoma).