D
Douglas Lane
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 24
Citations - 974
Douglas Lane is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Bacillus anthracis & Burkholderia mallei. The author has an hindex of 13, co-authored 23 publications receiving 945 citations. Previous affiliations of Douglas Lane include Science Applications International Corporation & United States Department of the Army.
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Journal ArticleDOI
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Rekha G. Panchal,Gordon Ruthel,Tara Kenny,George Kallstrom,Douglas Lane,Shirin S. Badie,Limin Li,Sina Bavari,M. Javad Aman +8 more
TL;DR: By mutagenesis, this work identifies several critical C-terminal sequences that regulate oligomerization at the plasma membrane, association with detergent-resistant membranes, and vesicular release of VP40, directly linking these phenomena.
Journal ArticleDOI
Identification of small molecule inhibitors of anthrax lethal factor
Rekha G. Panchal,Ann R. Hermone,Tam Luong Nguyen,Thiang Yian Wong,Robert Schwarzenbacher,James J. Schmidt,Douglas Lane,Connor F. McGrath,Benjamin E. Turk,James C. Burnett,M. Javad Aman,Stephen F. Little,Edward A. Sausville,Daniel W. Zaharevitz,Lewis C. Cantley,Robert C. Liddington,Rick Gussio,Sina Bavari +17 more
TL;DR: Six inhibitors of LF are described on the basis of a pharmacophoric relationship determined using X-ray crystallographic data, molecular docking studies and three-dimensional (3D) database mining from the US National Cancer Institute (NCI) chemical repository.
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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
James C. Burnett,James J. Schmidt,Robert G. Stafford,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Jonathan L. Vennerstrom,Connor F. McGrath,Douglas Lane,Edward A. Sausville,Daniel W. Zaharevitz,Rick Gussio,Sina Bavari +12 more
TL;DR: This is the first study to report small molecules (non-peptidics) that inhibit BoNT/A LC metalloprotease activity in the low microM range.
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Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C. Burnett,Gordon Ruthel,Christian Stegmann,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Robert G. Stafford,Douglas Lane,Tara Kenny,Connor F. McGrath,Peter Wipf,Andrea M. Stahl,James J. Schmidt,Rick Gussio,Axel T. Brunger,Sina Bavari +15 more
TL;DR: Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein in a primary culture of embryonic chicken neurons.
Journal ArticleDOI
Anthrax Lethal Toxin Impairs Innate Immune Functions of Alveolar Macrophages and Facilitates Bacillus anthracis Survival
Wilson J. Ribot,Rekha G. Panchal,Katherine C. Brittingham,Gordon Ruthel,Tara Kenny,Douglas Lane,Bob Curry,Timothy A. Hoover,Arthur M. Friedlander,Sina Bavari +9 more
TL;DR: The data imply that cytolysis does not correlate with MEK1 cleavage, and this is the first report of LT-mediated impairment of nonhuman primate AM bactericidal activity against B. anthracis.