Richard D. McFarland

TL;DR: It is found that, although thymic function declines with age, substantial output is maintained into late adulthood and this results indicate that the adult thymus can contribute to immune reconstitution following HAART.

TL;DR: It is demonstrated that alphaE integrin (CD103) expression is up-regulated very late in thymic development on a subset of CD8(+)/CD4(-) thymocytes and also defines a distinct subset of naiveCD8(+) T cells in the periphery, which suggest that these cells are a population of RTE and that quantification of their frequency in peripheral blood provides an estimate of the level of ongoing thymopoiesis.

TL;DR: Investigation of the role of the thymus in T cell reconstitution in human immunodeficiency virus (HIV)-infected children treated with antiretroviral therapy suggests that HIV has an adverse effect upon thymic function in pediatric HIV infection.

TL;DR: The findings of erythroid maturation and abundant viral inclusions in these immunocompromised patients is consistent with the hypothesis that failure to produce effective IgG parvovirus neutralizing antibodies may lead to persistent infection through viral tolerance that allows erythyroid development of infected cells past the pronormoblast stage.

TL;DR: This article used a lentivirus-based gene transfer system to mark CD34 + cells with EGFP and follow their differentiation into CD4 + and CD8 + single positive thymocytes in human thymic organ cultures.