Journal ArticleDOI
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TLDR
Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.Abstract:
The Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are among the most promising new targets for cancer therapy. In addition to interleukin-6 (IL-6) and its family members, multiple pathways, including G-protein-coupled receptors (GPCRs), Toll-like receptors (TLRs) and microRNAs were recently identified to regulate JAK-STAT signalling in cancer. Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK-STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche. In addition to its established role as a transcription factor in cancer, STAT3 regulates mitochondrion functions, as well as gene expression through epigenetic mechanisms. Newly identified regulators and functions of JAK-STAT3 in tumours are important targets for potential therapeutic strategies in the treatment of cancer.read more
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Macrophages and Therapeutic Resistance in Cancer
Brian Ruffell,Lisa M. Coussens +1 more
TL;DR: This review discusses the molecular/cellular pathways identified so far whereby macrophages mediate therapeutic responses and therapeutics impacting macrophage presence and/or bioactivity have shown promise in preclinical models and are now being evaluated in the clinic.
Journal ArticleDOI
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin,Soma Kobayashi,Andrew Leader,El-ad David Amir,Naama Elefant,Camille Bigenwald,Romain Remark,Robert Sweeney,Christian Becker,Jacob H. Levine,Klaus Meinhof,Andrew Chow,Seunghee Kim-Shulze,Andrea S. Wolf,Chiara Medaglia,Hanjie Li,Julie A. Rytlewski,Ryan O. Emerson,Alexander Solovyov,Benjamin Greenbaum,Catherine Sanders,Marissa Vignali,Mary Beth Beasley,Raja M. Flores,Sacha Gnjatic,Dana Pe'er,Adeeb Rahman,Ido Amit,Miriam Merad +28 more
TL;DR: It is shown that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments, andaired single-cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies.
Journal ArticleDOI
Therapeutic cancer vaccines
TL;DR: The clinical benefit of therapeutic cancer vaccines has been established and the specificity of therapeutic vaccination combined with such immunomodulation offers an attractive avenue for the development of future cancer therapies.
Journal ArticleDOI
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
TL;DR: The key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses are considered, which highlight the potential of targeting IL- 6 family members to treat inflammatory diseases and cancer.
Journal ArticleDOI
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.
Yi-Zhou Jiang,Ding Ma,Chen Suo,Shi Jinxiu,Mengzhu Xue,Xin Hu,Yi Xiao,Ke Da Yu,Yi Rong Liu,Ying Yu,Yuanting Zheng,Xiangnan Li,Chen-Hui Zhang,Peng-Chen Hu,Jing Zhang,Qi Hua,Jiyang Zhang,Wanwan Hou,Luyao Ren,Ding Bao,B. Li,Jingcheng Yang,Ling Yao,Wen Jia Zuo,Shen Zhao,Yue Gong,Yi Xing Ren,Ya Xin Zhao,Yun Song Yang,Niu Zhenmin,Zhi Gang Cao,Daniel G. Stover,Claire F. Verschraegen,Virginia G. Kaklamani,Anneleen Daemen,John R. Benson,Kazuaki Takabe,Fan Bai,Da Qiang Li,Peng Wang,Leming Shi,Wei Huang,Zhi Ming Shao +42 more
TL;DR: The LAR subtype showed more ERBB2 somatic mutations, infrequent mutational signature 3 and frequent CDKN2A loss than the other subtypes, and was classified as a mesenchymal-like subtype.
References
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Journal ArticleDOI
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Journal ArticleDOI
STATs in cancer inflammation and immunity: a leading role for STAT3
TL;DR: Signal transducer and activator of transcription proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer, and STAT3 is a promising target to redirect inflammation for cancer therapy.