J
Jose L. Fernandez-Luna
Researcher at Washington University in St. Louis
Publications - 84
Citations - 8697
Jose L. Fernandez-Luna is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Kinase & Apoptosis. The author has an hindex of 35, co-authored 76 publications receiving 8219 citations. Previous affiliations of Jose L. Fernandez-Luna include Genentech.
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Journal ArticleDOI
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
Robyn Catlett-Falcone,Terry H. Landowski,Marc M. Oshiro,James Turkson,Alexander Levitzki,Rocco Savino,Gennaro Ciliberto,Lynn C. Moscinski,Jose L. Fernandez-Luna,Gabriel Núñez,William S. Dalton,Richard Jove +11 more
TL;DR: Findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis.
Journal ArticleDOI
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE
Naohiro Inohara,Yasunori Ogura,Ana Fontalba,Olga Gutierrez,F. Pons,Javier Crespo,Koichi Fukase,Seiichi Inamura,Shoichi Kusumoto,Masahito Hashimoto,Simon J. Foster,Anthony P. Moran,Jose L. Fernandez-Luna,Gabriel Núñez +13 more
TL;DR: NOD2 mediates the host response to bacterial muropeptides derived from peptidoglycan, an activity that is important for protection against Crohn's disease and has implications for understanding adjuvant function and effective vaccine development.
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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation
Olga Gutierrez,Carlos Pipaon,Naohiro Inohara,Ana Fontalba,Yasunori Ogura,Felipe Prosper,Gabriel Núñez,Jose L. Fernandez-Luna +7 more
TL;DR: In this paper, expression of Nod2 is induced upon differentiation of CD34(+) hematopoietic progenitor cells into granulocyte or monocyte/macrophages.
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Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL
Machiko Horita,Enrique J. Andreu,Adalberto Benito,Cristina Arbona,Cristina Sanz,I Benet,Felipe Prosper,Jose L. Fernandez-Luna +7 more
TL;DR: It is shown that the interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL, is induced by Bcr-Abl through activation of signal transducer and activator of transcription (Stat)5.
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Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2
Maite Silva,Didier A.M. Grillot,Adalberto Benito,Carlos Richard,Gabriel Núñez,Jose L. Fernandez-Luna +5 more
TL;DR: It is shown that HCD-57 rescued from apoptosis by ectopic expression of Bcl-XL can undergo erythroid differentiation in the absence of Epo, demonstrating that a survival signal but not Epo itself is necessary for erythyroid differentiation of H CD-57 progenitor cells.