Claire Emson

TL;DR: It is reported that Th2 cell cultures generated using T cells or splenocytes from IL-13-deficient mice produce significantly reduced levels of IL-4, IL-5, and IL-10 compared with wild-type, suggesting IL- 13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases.

TL;DR: It is concluded that IL-4 and IL-13 cooperate to initiate rapid Th2 cell–driven responses, and that although their functions overlap, they perform additive roles.

TL;DR: It is found that these Th2 cytokines are not essential for fetal survival even during allogeneic pregnancy, and a threshold is reached at which IL-4 alone can activate all Th2 effector functions.

TL;DR: The data are the first to provide experimental proof that the adaptive immune response to a soluble antigen is sufficient to cause severe pulmonary arterial muscularization, and support the clinical observations in pediatric patients and in companion animals that muscularization represents one of several injurious events to the pulmonary artery that may collectively contribute to PAH.

TL;DR: Expiration of IL-13 transgenes in vivo can regulate IgE production in the mouse, and thatIL-13 may also influence thymocyte development, according to histological examination.