A distinct role for interleukin-13 in Th2-cell-mediated immune responses
TLDR
It is demonstrated that, unlike wild-type and IL-4-/- mice, the IL-13-/- animals failed to clear N. brasiliensis infections efficiently, despite developing a robust Th2-like cytokine response to infection, and this observation may linkIL-13 with the production of intestinal mucus which is believed to facilitate worm expulsion.About:
This article is published in Current Biology.The article was published on 1998-03-12 and is currently open access. It has received 369 citations till now. The article focuses on the topics: Nippostrongylus brasiliensis & Immune system.read more
Citations
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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
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Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhou Zhu,Robert J. Homer,Robert J. Homer,Zhonde Wang,Qingsheng Chen,Gregory P. Geba,Gregory P. Geba,Jingming Wang,Yong Zhang,Jack A. Elias +9 more
TL;DR: The targeted pulmonary expression of IL-13 causes a mononuclear and eosinophilic inflammatory response, mucus cell metaplasia, airway fibrosis, eotaxin production, airways obstruction, and nonspecific AHR in transgene-positive animals.
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IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
Madeline M. Fort,Jeanne Cheung,David C. Yen,Joana Li,Sandra Zurawski,Sylvia Lo,Satish Menon,Teresa Clifford,Brisdell Hunte,Robin Lesley,Tony Muchamuel,Stephen D. Hurst,Gerard Zurawski,Michael W. Leach,Daniel M. Gorman,Donna Rennick +15 more
TL;DR: The results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types.
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Immunologic basis of antigen-induced airway hyperresponsiveness
TL;DR: Current understanding of the pathophysiologic mechanisms by which Th2 cytokines induce airway disease, and the factors that predispose to the generation of these pathogenic cells in response to inhalation of ubiquitous aero-allergens are discussed.
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IL-13 Effector Functions*
TL;DR: IL-13 was revealed as a potent mediator of tissue fibrosis in both schistosomiasis and asthma, which indicates that it is a key regulator of the extracellular matrix.
References
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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Generation and analysis of interleukin-4 deficient mice.
TL;DR: Some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo, but the serum levels of IgG1 and IgE are strongly reduced.
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Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Manfred Kopf,G. Le Gros,Martin F. Bachmann,Marinus C. Lamers,Horst Bluethmann,Georges Köhler +5 more
TL;DR: It is concluded that IL-4 is required for the generation of the Th2-derived cytokines and that immune responses dependent on these cytokines are impaired.
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Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
G Zurawski,Jan E. de Vries +1 more
TL;DR: The data shows that IL-13 shares biological activities with IL-4, their genes are closely linked in both the human and mouse genomes, and there is sequence homology between IL-11 and IL-12 proteins.
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The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
Jian-Xin Lin,Thi-Sau Migone,Monica Tseng,Michael Friedmann,James A. Weatherbee,Li Zhou,Akira Yamauchi,Eda T. Bloom,Judy A. Mietz,Susan D. John,Warren J. Leonard +10 more
TL;DR: These studies demonstrate that a single cytokine can activate different combinations of Stat proteins under different physiological conditions, and also indicate two mechanisms by which distinct cytokines can activate the same Stat protein.