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Richard M. Epand
Researcher at McMaster University
Publications - 521
Citations - 26937
Richard M. Epand is an academic researcher from McMaster University. The author has contributed to research in topics: Membrane & Peptide. The author has an hindex of 80, co-authored 515 publications receiving 25125 citations. Previous affiliations of Richard M. Epand include Brigham Young University & University of Edinburgh.
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Journal ArticleDOI
Ceragenins: Cholic Acid Based Mimics of Antimicrobial Peptides
Xin Zhong Lai,Yanshu Feng,Jacob Pollard,Judy N. Chin,Michael J. Rybak,Robert Bucki,Raquel F. Epand,Richard M. Epand,Paul B. Savage +8 more
TL;DR: The ceragenins as mentioned in this paper were developed to mimic the cationic, facially amphiphilic structures of most antimicrobial peptides and reproduce the required morphology using a bile-ac...
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Role of peptide structure in lipid-peptide interactions: nuclear magnetic resonance study of the interaction of pentagastrin and [Arg4]pentagastrin with dimyristolyphosphatidylcholine
TL;DR: The results clearly demonstrate the importance of peptide charge in determining the effects of peptides on lipid bilayers.
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A densitometric study of the effects of free fatty acids on the phase transition of dimyristoylphosphatidylcholine bilayers
D. Fodor,Richard M. Epand +1 more
TL;DR: The technique of scanning densitometry was applied to a study of the effect of fatty acids on the packing and phase transition properties of dimyristolyphosphaticylcholine and it was observed thatPalmitic and behenic acids broaden the phase transition toward higher temperatures while palmitoleic broadens it toward lower temperatures.
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Studies on the alkaline denaturation of glucagon.
Richard M. Epand,Raquel F. Epand +1 more
TL;DR: In solutions at high pH, amino acid residues of glucagon undergo racemization without cleavage of the polypeptide backbone, accompanied by an unfolding of the molecule with the loss of both its antigenicity and its ability to stimulate adenyl cyclase from rat liver.
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α-Synuclein and neuronal membranes: Conformational flexibilities in health and disease.
TL;DR: In this paper, a review of the intricate interactions between α-synuclein and membranes is reviewed and a discussion of the relationship between αS and neuronal membrane structural plasticity in health and disease will be made.