R
Richard M. Epand
Researcher at McMaster University
Publications - 521
Citations - 26937
Richard M. Epand is an academic researcher from McMaster University. The author has contributed to research in topics: Membrane & Peptide. The author has an hindex of 80, co-authored 515 publications receiving 25125 citations. Previous affiliations of Richard M. Epand include Brigham Young University & University of Edinburgh.
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Journal ArticleDOI
Discovery of an antivirulence compound that reverses β -lactam resistance in MRSA
Omar M. El-Halfawy,Omar M. El-Halfawy,Tomasz L. Czarny,Ronald S. Flannagan,Jonathan Day,José Carlos Bozelli,Robert C. Kuiack,Ahmed Salim,Philip Eckert,Richard M. Epand,Martin J. McGavin,Michael G. Organ,Michael G. Organ,David E. Heinrichs,Eric D. Brown +14 more
TL;DR: A potent inhibitor of the MRSA virulence regulator, GraR, reverses methicillin resistance, inhibits biofilm formation, limits bacterial survival in macrophages and attenuates virulence in vitro, synergizing with cationic antimicrobial peptides.
Journal ArticleDOI
High Temperature Stabilization of DNA in Complexes with Cationic Lipids
Yury S. Tarahovsky,Yury S. Tarahovsky,Vera A. Rakhmanova,Richard M. Epand,Robert C. MacDonald +4 more
TL;DR: Constant constraint of the DNA molecules between oppositely charged membrane surfaces in the multilamellar complex is responsible for DNA stabilization.
Journal ArticleDOI
Dimerization of the P-glycoprotein in membranes.
Daniel Boscoboinik,Maria Theresa Debanne,Alan R. Stafford,Chan Y. Jung,Radhey S. Gupta,Richard M. Epand +5 more
TL;DR: Strong evidence to indicate that the P-glycoprotein self associates in the membrane is found, using radiation inactivation analysis of plasma membranes from a CHO cell line, CHRC5, which exhibits multidrug resistance.
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Effects of the ‘fusion peptide’ from measles virus on the structure of N-methyl dioleoylphosphatidylethanolamine membranes and their fusion with Sendai virus
TL;DR: Enhanced fusion of octadecyl rhodamine-labelled Sendai virus with N-methyl dioleoylphosphatidylethanolamine large unilamellar vesicles was observed when the 'fusion peptide' was incorporated into the large unILamellars vesicle.
Journal ArticleDOI
Modulation of lipid polymorphism by the feline leukemia virus fusion peptide: Implications for the fusion mechanism
TL;DR: This work provides the first published experimental evidence of both fusogenic activity and effects on lipid polymorphism for the FeLV fusion peptide.