Richard M. Epand

TL;DR: Stored curvature strain energy is an important determinant of CT activation and may reflect an increased surface hydrophobicity of class II lipid membranes, implying a role for surface dehydration in CT's interactions with membranes containing class II lipids.

TL;DR: Using solution methodologies, a series of analogues of trichogin GA IV was synthesized which allowed determination of the minimal lipid chain and peptide main-chain lengths for the onset of membrane activity and exploitation of a number of spectroscopic techniques aimed at determining its preferred conformation under a variety of conditions.

TL;DR: The activation of the plasma enzyme lecithin: cholesterol acyltransferase by the Ac‐18A‐NH2 peptide is greater than the 18A analog and comparable to that observed with the apo A‐I, which is the major protein component of high‐density lipoprotein and a potent inhibitor of lipid hexagonal phase formation.

TL;DR: The ability of human calcitonin to solubilize dimyristoylphosphatidylglycerol and to alter the phase transition properties of this phospholipid while maintaining a low content of helix indicates that the presence of an amphipathic helix is not a requirement for these effects.

TL;DR: A remarkable correlation was found between the net positive charge of the peptides and their capacity to induce anionic lipid clustering, which was independent of their secondary structure and likely contributes to the mechanism of antibacterial action of highly cationic CPPs.