R
Richard M. Epand
Researcher at McMaster University
Publications - 521
Citations - 26937
Richard M. Epand is an academic researcher from McMaster University. The author has contributed to research in topics: Membrane & Peptide. The author has an hindex of 80, co-authored 515 publications receiving 25125 citations. Previous affiliations of Richard M. Epand include Brigham Young University & University of Edinburgh.
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Journal ArticleDOI
Design and Characterization of a Broad -Spectrum Bactericidal Acyl-lysyl Oligomer
Liran Livne,Tchelet Kovachi,Hadar Sarig,Raquel F. Epand,Fadia Zaknoon,Richard M. Epand,Amram Mor +6 more
TL;DR: Investigation of OAK sequences and characterized a promising representative, designated C(12)K-3beta(10), with broad-spectrum activity and low hemotoxicity, which demonstrated the OAK's ability to significantly affect bacterial viability upon single-dose systemic treatment.
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Role of the Glu residues of the influenza hemagglutinin fusion peptide in the pH dependence of fusion activity.
TL;DR: It is concluded that conformational changes are tightly coupled to fusion peptide insertion in the overall HA-mediated fusion cascade.
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CTP:phosphocholine cytidylyltransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcholine.
Adrienne E. Drobnies,Sarah M. A. Davies,Ruud Kraayenhof,Raquel F. Epand,Richard M. Epand,Rosemary B. Cornell +5 more
TL;DR: It is shown that 1-palmitoyl, 2-(11,15 dihydroxy) eicosatrienoyl PC (diOH-PAPC) caused less of an increase in the temperature of the lamellar to hexagonal II transition (T(H)) of an unsaturated PE, compared to its parent, PAPC.
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Role of prenylation in the interaction of the a-factor mating pheromone with phospholipid bilayers.
TL;DR: The results indicate that the farnesyl group alone, in the absence of cellular factors, bestows a particular physical interaction with membranes.
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Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids.
Raquel F. Epand,Vinod K. Mishra,Mayakonda N. Palgunachari,Gattadahalli M. Anantharamaiah,Richard M. Epand +4 more
TL;DR: There is a correlation between the biological potency of these peptides and their ability to interact with certain specific cytotoxic lipids, suggesting that this interaction may contribute favourably to their biological properties.