Richard M. Epand

TL;DR: The ionophore A23 187 in the presence of Ca2+ also induces PG release from PMNL and is compared to the release of lysosomal enzymes and is shown to induce phagocytosis-associated responses in PMNL.

TL;DR: The variations in antimicrobial activity among the authors' peptides are correlated with the folding propensities of these molecules and with the extent to which the peptides induce leakage of contents from synthetic liposomes, which suggests that the biological effects of high salt concentrations arise from modulation of peptide-membrane interactions.

TL;DR: Findings indicate that DTMAC, which does not contain a group to fix its location along the bilayer normal, adjusts its position to small changes in environment polarity, so as to maintain an environment of a fixed dielectric constant, however, with greater changes in membrane interfacial polarity the environment of the probe will be altered.

TL;DR: This work shows that variations in the selectivity of these peptidic antimicrobial peptides toward different strains of bacteria can be partly determined by the lipid composition of the bacterial cell membrane.

TL;DR: The rate of formation of high-curvature intermediates or disordered cubic phases in N-methyldioleoylphosphatidylethanolamine (N-methyl-DOPE) dispersions with or without additives was studied by 31P NMR spectroscopy.