Risa Burr

TL;DR: It is shown that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic, and a machine-learning method termed ‘lung cancer likelihood in plasma’ (Lung-CLiP) is developed, which can robustly discriminate early-Stage lung cancer patients from risk-matched controls.

TL;DR: It is shown that single CTCs from melanoma patients coordinately upregulate lipogenesis and iron homeostasis pathways, correlated with both intrinsic and acquired resistance to BRAF inhibitors across clonal cultures of BRAF-mutant C TCs.

TL;DR: A tumor-stromal paracrine pathway in which secretion by tumor cells of the COX-2 product prostaglandin E2 induces prolactin production by stromal cells, which activates signaling in disseminated tumor cells with upregulated Prolactin receptor expression is uncovered.

TL;DR: The involvement of epithelial-mesenchymal plasticity in the early steps of metastasis and what is learned about its contribution to genomic instability and genetic diversity, tumor progression and therapeutic responses are reviewed using cell culture, mouse models and circulating tumor cells enriched from patients.

TL;DR: In this paper, the orphan nuclear receptor NR4A1 localizes across the gene body and 3′ UTR of IEGs, where it inhibits transcriptional elongation by RNA Pol II, generating R-loops and accessible chromatin domains.