Riyad N.H. Seervai

TL;DR: Comprehensive genomic and transcriptomic profiling of untreated primary RMC tissues found that RMC was characterized by high replication stress and an abundance of focal copy-number alterations associated with activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) innate immune pathway.

TL;DR: These experiments demonstrate distinct pathways by which a parasexual cycle can occur in C. tropicalis and indicate that nonmeiotic mechanisms drive ploidy changes in this prevalent human pathogen.

TL;DR: The hypothesis that the transition between these determination mechanisms is more of a continuum than a binary change is discussed, and an analogy between germline determination and sex determination in vertebrates—two of the milestones of reproduction and development—is proposed.

TL;DR: This work shows that SETD2 is an actin methyltransferase that trimethylates lysine-68 (ActK68me3) in cells via its interaction with HTT and the actin-binding adapter HIP1R and identifies it as a previously unknown HTT effector regulating methylation and polymerization of actin filaments.

TL;DR: In this paper, the authors show that the coordinated read-write activity of the epigenetic machinery extends to the cytoskeleton, with PBRM1 in the PBAF chromatin remodeling complex reading microtubule methyl marks written by the SETD2 histone methyltransferase.