R
Robert E. Gerszten
Researcher at Beth Israel Deaconess Medical Center
Publications - 337
Citations - 32894
Robert E. Gerszten is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 78, co-authored 257 publications receiving 26320 citations. Previous affiliations of Robert E. Gerszten include Beth Israel Deaconess Hospital & Broad Institute.
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Journal ArticleDOI
Probing the Virtual Proteome to Identify Novel Disease Biomarkers
Jonathan D. Mosley,Mark D. Benson,J. Gustav Smith,Olle Melander,Debby Ngo,Christian M. Shaffer,Jane F. Ferguson,Matthew Herzig,Catherine A. McCarty,Christopher G. Chute,Gail P. Jarvik,Adam S. Gordon,Melody R. Palmer,David R. Crosslin,Eric B. Larson,Eric B. Larson,David Carrell,Iftikhar J. Kullo,Jennifer A. Pacheco,Peggy L. Peissig,Murray H. Brilliant,Terrie Kitchner,James G. Linneman,Bahram Namjou,Marc S. Williams,Marylyn D. Ritchie,Kenneth M. Borthwick,Krzysztof Kiryluk,Frank D. Mentch,Patrick M. A. Sleiman,Elizabeth W. Karlson,Shefali S. Verma,Yineng Zhu,Ramachandran S. Vasan,Qiong Yang,Josh C. Denny,Dan M. Roden,Robert E. Gerszten,Thomas J. Wang +38 more
TL;DR: A “virtual proteomic” approach, linking genetically predicted protein levels to clinical diagnoses in >40 000 individuals and demonstrating a biomarker discovery paradigm to identify candidate biomarkers of cardiovascular and other diseases is demonstrated.
Journal ArticleDOI
Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions.
Jaison Jacob,Debby Ngo,Nancy Finkel,Rebecca Pitts,Scott Gleim,Mark D. Benson,Michelle J. Keyes,Laurie A. Farrell,Thomas Morgan,Lori L. Jennings,Robert E. Gerszten +10 more
TL;DR: The results demonstrate the feasibility of large-scale aptamer multiplexing at a level that has not previously been reported and with sample throughput that greatly exceeds other existing proteomic methods.
Journal ArticleDOI
Metabolites Associated With Lean Mass and Adiposity in Older Black Men.
Rachel A. Murphy,Steven C. Moore,Mary C. Playdon,Osorio Meirelles,Anne B. Newman,Iva Milijkovic,Stephen B. Kritchevsky,Ann V. Schwartz,Bret H. Goodpaster,Joshua N. Sampson,Peggy M. Cawthon,Peggy M. Cawthon,Eleanor M. Simonsick,Robert E. Gerszten,Clary B. Clish,Tamara B. Harris +15 more
TL;DR: Findings confirm prior reports of associations between amino acids, lean mass, and fat mass in addition to associations not previously reported, and consider whether these metabolites are relevant for metabolic disease processes.
Journal ArticleDOI
Biomarker Discovery and Validation
TL;DR: A global survey is used to identify potential new markers related specifically to brain injury and the long road toward validation of these markers in clinically relevant human cohorts is described.
Journal ArticleDOI
Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study
Darae Ko,Mark D. Benson,Debby Ngo,Qiong Yang,Martin G. Larson,Thomas J. Wang,Ludovic Trinquart,David D. McManus,Steven A. Lubitz,Patrick T. Ellinor,Ramachandran S. Vasan,Robert E. Gerszten,Emelia J. Benjamin,Honghuang Lin +13 more
TL;DR: Future studies are needed to replicate the findings, identify whether the markers are mechanistically related to AF development, and whether they are clinically useful for identification of future AF risk.