B
Bahram Namjou
Researcher at University of Cincinnati
Publications - 50
Citations - 3493
Bahram Namjou is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Lupus erythematosus & Population. The author has an hindex of 25, co-authored 38 publications receiving 3047 citations. Previous affiliations of Bahram Namjou include Cincinnati Children's Hospital Medical Center & Oklahoma Medical Research Foundation.
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Journal ArticleDOI
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
John B. Harley,John B. Harley,John B. Harley,Marta E. Alarcón-Riquelme,Lindsey A. Criswell,Chaim O. Jacob,Robert P. Kimberly,Kathy L. Moser,Kathy L. Moser,Betty P. Tsao,Timothy J. Vyse,Carl D. Langefeld,Swapan K. Nath,Joel M. Guthridge,Beth L. Cobb,Daniel B. Mirel,Miranda C. Marion,Adrienne H. Williams,Jasmin Divers,Wei Wang,Summer G. Frank,Bahram Namjou,Stacey Gabriel,Annette Lee,Peter K. Gregersen,Timothy W. Behrens,Timothy W. Behrens,Kimberly E. Taylor,Michelle M. A. Fernando,Raphael Zidovetzki,Patrick M. Gaffney,Patrick M. Gaffney,Jeffrey C. Edberg,John D. Rioux,Joshua O. Ojwang,Judith A. James,Joan T. Merrill,Gary S. Gilkeson,Michael F. Seldin,Hong Yin,Emily C. Baechler,Quan Zhen Li,Edward K. Wakeland,Gail R. Bruner,Kenneth M. Kaufman,Kenneth M. Kaufman,Jennifer A. Kelly +46 more
TL;DR: The results show that numerous genes, some with known immune-related functions, predispose to SLE, and evidence of association with replication is found at FCGR2A, PTPN22 and STAT4, regions previously associated with SLE and other autoimmune diseases.
Journal ArticleDOI
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome
R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Gail R. Bruner,Bahram Namjou,Robert P. Kimberly,Rosalind Ramsey-Goldman,Michelle Petri,John D. Reveille,Graciela S. Alarcón,Luis M. Vilá,Jeff Reid,Bryan Harris,Shibo Li,Jennifer A. Kelly,John B. Harley,John B. Harley +16 more
TL;DR: The frequency of Klinefelter's syndrome (47,XXY), often subclinical, is increased in men with SLE by approximately 14-fold compared with its prevalence in men without SLE, consistent with the notion that SLE susceptibility is partly explained by an X chromosome gene-dose effect.
Journal ArticleDOI
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
Bahram Namjou,Parul H. Kothari,Jennifer A. Kelly,Stuart B. Glenn,Joshua O. Ojwang,Adam Adler,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Caroline J. Gallant,Susan A. Boackle,Lindsey A. Criswell,Robert P. Kimberly,Elizabeth E. Brown,Jeffrey C. Edberg,Anne M. Stevens,Chaim O. Jacob,Betty P. Tsao,Gary S. Gilkeson,Diane L. Kamen,Joan T. Merrill,Michelle Petri,R. R. Goldman,Luis M. Vilá,J-M Anaya,Timothy B. Niewold,Javier Martin,Bernardo A. Pons-Estel,José Mario Sabio,José Luis Callejas,Timothy J. Vyse,S-C Bae,Fred W. Perrino,Barry I. Freedman,Scofield Rh,Kathy L. Moser,Patrick M. Gaffney,Judith A. James,Carl D. Langefeld,Kenneth M. Kaufman,Kenneth M. Kaufman,John B. Harley,John P. Atkinson +42 more
TL;DR: Analysis of common TREX1 SNPs revealed a relatively common risk haplotype in European SLE patients with neurological manifestations, especially seizures, with a frequency of 58% in lupus cases compared with 45% in normal controls, and a strong association with anti-nRNP was observed.
Journal ArticleDOI
Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus.
Swapan K. Nath,Jennifer A. Kelly,Bahram Namjou,Tom Lam,Gail R. Bruner,R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Christopher E. Aston,John B. Harley,John B. Harley,John B. Harley +11 more
TL;DR: The hypotheses that SLE and vitiligo may share important genetic effects and that sampling on the basis of clinical covariates dramatically improves power to identify genetic effects are supported.
Journal ArticleDOI
The genetics of systemic lupus erythematosus and implications for targeted therapy
TL;DR: Genetic studies are likely to suggest novel molecular targets for strategic development of safer and more effective therapeutics, and provide insights into fundamental disease pathology as well as contributing to informed patient selection for targeted treatments and biomarkers to guide dosing and gauge responsiveness.