Q
Qing Yuan
Researcher at University of Texas Southwestern Medical Center
Publications - 49
Citations - 2596
Qing Yuan is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Magnetic resonance imaging & Imaging phantom. The author has an hindex of 19, co-authored 47 publications receiving 1958 citations. Previous affiliations of Qing Yuan include University of Pennsylvania & Children's Medical Center of Dallas.
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Journal ArticleDOI
Lactate Metabolism in Human Lung Tumors
Brandon Faubert,Kevin Y. Li,Ling Cai,Christopher T. Hensley,Jiyeon Kim,Lauren G. Zacharias,Chendong Yang,Quyen N. Do,Sarah Doucette,Daniel Burguete,Hong Li,Giselle Huet,Qing Yuan,Trevor Wigal,Yasmeen M. Butt,Min Ni,Jose R. Torrealba,Dwight H Oliver,Robert E. Lenkinski,Craig R. Malloy,Jason W Wachsmann,Jamey D. Young,Kemp H. Kernstine,Ralph J. DeBerardinis +23 more
TL;DR: The data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo, and directly comparing lactate and glucose metabolism in vivo indicated that lactate's contribution to the TCA cycle predominates.
Journal ArticleDOI
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley,Brandon Faubert,Qing Yuan,Naama Lev-Cohain,Eunsook S. Jin,Jiyeon Kim,Lei Jiang,Bookyung Ko,Rachael Skelton,Laurin Loudat,Michelle Wodzak,Claire Klimko,Elizabeth A. McMillan,Yasmeen M. Butt,Min Ni,Dwight H Oliver,Jose R. Torrealba,Craig R. Malloy,Kemp H. Kernstine,Robert E. Lenkinski,Ralph J. DeBerardinis +20 more
TL;DR: These findings not only demonstrate the heterogeneity in tumor metabolism in vivo but also highlight the strong influence of the microenvironment on this feature.
Journal ArticleDOI
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma.
Kevin D. Courtney,Yuanqing Ma,Alberto Diaz de Leon,Alana Christie,Zhiqun Xie,Layton Woolford,Nirmish Singla,Allison Joyce,Haley Hill,Ananth J. Madhuranthakam,Qing Yuan,Yin Xi,Yue Zhang,Jenny Chang,Oluwatomilade Fatunde,Yull Edwin Arriaga,Arthur E. Frankel,Sanjeeva P. Kalva,Song Zhang,Tiffani McKenzie,Oscar Reig Torras,Robert A. Figlin,Brian I. Rini,Renée M. McKay,Payal Kapur,Tao Wang,Ivan Pedrosa,James Brugarolas +27 more
TL;DR: Findings demonstrate a core dependency on Hif-2 in metastatic ccRCC and establish PT2385 as a highly specific HIF-2 inhibitor in humans and establish new approaches will be required to target mutant H IF-2 beyondPT2385 or the closely related PT2977.
Journal ArticleDOI
Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.
Diego Hernando,Samir D. Sharma,Mounes Aliyari Ghasabeh,Bret D. Alvis,Sandeep Arora,Gavin Hamilton,Li Pan,Jean Shaffer,Keitaro Sofue,Keitaro Sofue,Nikolaus M. Szeverenyi,E. Brian Welch,Qing Yuan,Mustafa R. Bashir,Ihab R. Kamel,Mark J. Rice,Claude B. Sirlin,Takeshi Yokoo,Scott B. Reeder +18 more
TL;DR: To evaluate the accuracy and reproducibility of quantitative chemical shift‐encoded (CSE) MRI to quantify proton‐density fat‐fraction (PDFF) in a fat–water phantom across sites, vendors, field strengths, and protocols.
Journal ArticleDOI
In vivo human cervical spinal cord deformation and displacement in flexion.
TL;DR: The cervical cord elongates and displaces significantly during head flexion in human volunteers, offering valuable information regarding the normal milieu of the cord.