J
Jamey D. Young
Researcher at Vanderbilt University
Publications - 109
Citations - 5737
Jamey D. Young is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Metabolic flux analysis & Flux (metabolism). The author has an hindex of 33, co-authored 96 publications receiving 4394 citations. Previous affiliations of Jamey D. Young include Vanderbilt University Medical Center & Massachusetts Institute of Technology.
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Journal ArticleDOI
Lactate Metabolism in Human Lung Tumors
Brandon Faubert,Kevin Y. Li,Ling Cai,Christopher T. Hensley,Jiyeon Kim,Lauren G. Zacharias,Chendong Yang,Quyen N. Do,Sarah Doucette,Daniel Burguete,Hong Li,Giselle Huet,Qing Yuan,Trevor Wigal,Yasmeen M. Butt,Min Ni,Jose R. Torrealba,Dwight H Oliver,Robert E. Lenkinski,Craig R. Malloy,Jason W Wachsmann,Jamey D. Young,Kemp H. Kernstine,Ralph J. DeBerardinis +23 more
TL;DR: The data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo, and directly comparing lactate and glucose metabolism in vivo indicated that lactate's contribution to the TCA cycle predominates.
Journal ArticleDOI
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg Martin Buescher,Maciek R. Antoniewicz,Laszlo G. Boros,Shawn C. Burgess,Henri Brunengraber,Clary B. Clish,Ralph J. DeBerardinis,Olivier Feron,Christian Frezza,Bart Ghesquière,Eyal Gottlieb,Karsten Hiller,Russell G. Jones,Jurre J. Kamphorst,Richard G. Kibbey,Alec C. Kimmelman,Jason W. Locasale,Sophia Y. Lunt,Oliver D. K. Maddocks,Craig R. Malloy,Christian M. Metallo,Emmanuelle J. Meuillet,Joshua Munger,Katharina Nöh,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser,Uwe Sauer,Gregory Stephanopoulos,Julie St-Pierre,Daniel A. Tennant,Christoph Wittmann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Alexei Vazquez,Karen H. Vousden,Jamey D. Young,Nicola Zamboni,Sarah-Maria Fendt +38 more
TL;DR: Key issues in interpreting (13)C metabolite labeling patterns are reviewed, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
Journal ArticleDOI
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
TL;DR: Developing a more nuanced understanding of the molecular mechanisms underlying NAFLD progression will lead to more targeted and effective therapeutics for this increasingly prevalent disease, which to date has no proven pharmacologic treatment to prevent or reverse its course.
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INCA: a computational platform for isotopically non-stationary metabolic flux analysis.
TL;DR: Isotopomer network compartmental analysis (INCA) is the first publicly available software package that can perform both steady-state metabolic flux analysis and isotopically non-stationary metabolic fluxAnalysis.
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Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis.
TL;DR: An approach to reconstruct comprehensive flux maps of photoautotrophic metabolism by computational analysis of dynamic isotope labeling measurements and has applied it to determine metabolic pathway fluxes in the cyanobacterium Synechocystis sp.