Z
Zhouji Chen
Researcher at Washington University in St. Louis
Publications - 52
Citations - 4328
Zhouji Chen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Fatty liver & Apolipoprotein B. The author has an hindex of 28, co-authored 47 publications receiving 3902 citations. Previous affiliations of Zhouji Chen include Discovery Institute & University of California, San Diego.
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Journal ArticleDOI
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Teresa C. Leone,John J. Lehman,Brian N. Finck,Paul J. Schaeffer,Adam R. Wende,Sihem Boudina,Michael Courtois,David F. Wozniak,Nandakumar Sambandam,Carlos Bernal-Mizrachi,Zhouji Chen,John O. Holloszy,Denis M. Medeiros,Robert E. Schmidt,Jeffrey E. Saffitz,E. Dale Abel,Clay F. Semenkovich,Daniel P. Kelly +17 more
TL;DR: It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
Journal ArticleDOI
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
Brian N. Finck,Matthew C. Gropler,Zhouji Chen,Teresa C. Leone,Michelle A. Croce,Thurl E. Harris,John C. Lawrence,Daniel P. Kelly +7 more
TL;DR: It is demonstrated that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivators controlling several key hepatic metabolic pathways.
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1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus
Jisu Oh,Sherry Weng,Shaili K. Felton,Sweety Bhandare,Amy E. Riek,Boyd Butler,Brandon M. Proctor,Marvin Petty,Zhouji Chen,Kenneth B. Schechtman,Leon Bernal-Mizrachi,Carlos Bernal-Mizrachi +11 more
TL;DR: Reduced vitamin D receptor signaling is identified as a potential mechanism underlying increased foam cell formation and accelerated cardiovascular disease in diabetic subjects.
Journal ArticleDOI
Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
Christoph Peter Gerhard Zechner,Ling Lai,Ling Lai,Juliet F. Zechner,Juliet F. Zechner,Tuoyu Geng,Zhen Yan,John W. Rumsey,Deanna Collia,Zhouji Chen,David F. Wozniak,Teresa C. Leone,Teresa C. Leone,Daniel P. Kelly,Daniel P. Kelly +14 more
TL;DR: It is concluded that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity.
Journal ArticleDOI
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
Elisa Fabbrini,Marina Cella,Steve A. Mccartney,Anja Fuchs,Nada A. Abumrad,Terri A. Pietka,Zhouji Chen,Brian N. Finck,Dong Ho Han,Faidon Magkos,Caterina Conte,David Bradley,Gemma Fraterrigo,Gemma Fraterrigo,J. Christopher Eagon,Bruce W. Patterson,Marco Colonna,Samuel Klein +17 more
TL;DR: Adipose tissue from MAO individuals contains increased numbers of Th17 and Th22 cells, which produce cytokines that cause metabolic dysfunction in liver and muscle in vitro, which contributes to the pathogenesis of insulin resistance in obese people.