Robert Hurwitz

TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.

TL;DR: This phospholipid represents a mycobacterial antigen recognized by T cells in the context of CD1d, thereby triggering antigen-specific IFN-gamma production and cell-mediated cytotoxicity.

TL;DR: It is demonstrated that AhR senses distinct bacterial virulence factors and controls antibacterial responses, supporting a previously unidentified role for AhR as an intracellular pattern recognition receptor, and identifying bacterial pigments as a new class of pathogen-associated molecular patterns.

TL;DR: It is shown here that CagAP‐Tyr inhibits the catalytic activity of c‐Src in vivo and in vitro and is the first report of a bacterial virulence factor that inhibits signalling of a eukaryotic tyrosine kinase and on a role of c-SRC inactivation in host cell cytoskeletal rearrangements.

TL;DR: It is demonstrated that CD4+ T cells control the CD8+ T cell response in two directions: Initially, they promote the generation of a CD8- T cell responses and later they restrain the strength of theCD8-T cell memory response.