R
Robert Hurwitz
Researcher at Max Planck Society
Publications - 61
Citations - 6269
Robert Hurwitz is an academic researcher from Max Planck Society. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 33, co-authored 58 publications receiving 5497 citations.
Papers
More filters
Journal ArticleDOI
Novel cell death program leads to neutrophil extracellular traps
Tobias A. Fuchs,Ulrike Abu Abed,Christian Goosmann,Robert Hurwitz,Ilka Schulze,Volker Wahn,Yvette Weinrauch,Volker Brinkmann,Arturo Zychlinsky +8 more
TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
Journal ArticleDOI
Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.
Karsten Fischer,Emmanuel Scotet,Marcus Niemeyer,Heidrun Koebernick,Jens Zerrahn,Sophie Maillet,Robert Hurwitz,Mischo Kursar,Marc Bonneville,Stefan H. E. Kaufmann,Ulrich E. Schaible +10 more
TL;DR: This phospholipid represents a mycobacterial antigen recognized by T cells in the context of CD1d, thereby triggering antigen-specific IFN-gamma production and cell-mediated cytotoxicity.
Journal ArticleDOI
AhR sensing of bacterial pigments regulates antibacterial defence
Pedro Moura-Alves,Kellen C. Faé,Erica Houthuys,Anca Dorhoi,Annika Kreuchwig,Jens Furkert,Nicola Barison,Anne Diehl,Antje Munder,Patricia Constant,Tatsiana Skrahina,Ute Guhlich-Bornhof,Marion Klemm,Anne-Britta Koehler,Silke Bandermann,Christian Goosmann,Hans-Joachim Mollenkopf,Robert Hurwitz,Volker Brinkmann,Simon Fillatreau,Mamadou Daffé,Burkhard Tümmler,Michael Kolbe,Hartmut Oschkinat,Gerd Krause,Stefan H. E. Kaufmann +25 more
TL;DR: It is demonstrated that AhR senses distinct bacterial virulence factors and controls antibacterial responses, supporting a previously unidentified role for AhR as an intracellular pattern recognition receptor, and identifying bacterial pigments as a new class of pathogen-associated molecular patterns.
Journal ArticleDOI
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.
Matthias Selbach,Stefan Moese,Robert Hurwitz,Christof R. Hauck,Thomas F. Meyer,Steffen Backert +5 more
TL;DR: It is shown here that CagAP‐Tyr inhibits the catalytic activity of c‐Src in vivo and in vitro and is the first report of a bacterial virulence factor that inhibits signalling of a eukaryotic tyrosine kinase and on a role of c-SRC inactivation in host cell cytoskeletal rearrangements.
Journal ArticleDOI
Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses.
Mischo Kursar,Kerstin Bonhagen,Joachim Fensterle,Anne Köhler,Robert Hurwitz,Thomas Kamradt,Stefan H. E. Kaufmann,Hans-Willi Mittrücker +7 more
TL;DR: It is demonstrated that CD4+ T cells control the CD8+ T cell response in two directions: Initially, they promote the generation of a CD8- T cell responses and later they restrain the strength of theCD8-T cell memory response.