Journal ArticleDOI
Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression
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TLDR
The hormonal regulation of casein gene expression appears to be an "all or none" process occurring only at the transcriptional or post-transcriptional levels, but may involve a coordinated response at several levels to permit the efficient expression of specialized differentiated functions.About:
This article is published in Cell.The article was published on 1979-08-01. It has received 438 citations till now. The article focuses on the topics: Casein & Prolactin.read more
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Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
TL;DR: It is clear that there are multiple actions associated with PRL, and the technique of gene targeting in mice has been used to develop the first experimental model in which the effect of the complete absence of any lactogen or PRL-mediated effects can be studied.
Journal ArticleDOI
The prolactin/growth hormone receptor family.
TL;DR: It is doubtful that one unifying mechanism of action will be found for this hormone, as several potential components of the signal transduction pathways have been identified, but as yet none has clearly been shown to be able to mimic the effect of PRL or GH.
Journal ArticleDOI
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
Richard L. Friedman,Susan P. Manly,Martin McMahon,Ian M. Kerr,George Stark Stark,George Stark Stark +5 more
TL;DR: Eighteen cDNAs, cloned from interferon-treated T98G neuroblastoma cells, correspond to seven different mRNAs induced up to 40-fold by interferons, and one codes for metallothionein II and another for a class I HLA.
Journal ArticleDOI
Variety in the level of gene control in eukaryotic cells
TL;DR: Definition of eukaryotic transcription units as simple and complex affords a framework in which to discuss control at the level of RNA processing for which several examples also are known.
Journal ArticleDOI
Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.
TL;DR: The precise temporal expression of these MHC genes in correlation with the myosin phenotype both during cardiac development and in response to different thyroid hormone levels are established and also document their expression in other muscle tissues.
References
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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
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125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
TL;DR: The data are consistent with a mechanism in which 125I-hEGF initially is bound to the cell surface and subsequently is internlized before degradation, and the binding capacity of these cells is restored by incubation in a serum-containing medium.
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Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid.
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Female steroid hormones and target cell nuclei.
TL;DR: The data discussed herein demonstrate the great variation in target-tissue response that can occur after administration of steroid hormones, and direct quantitative evidence that sex steroids cause a net increase in the intracellular amounts of specific mRNA molecules in target tissues is provided.
Journal ArticleDOI
Estrogen-Receptor Interaction
TL;DR: It is proposed that receptor transformation is an important step in estrogen action and that a principal role of the hormone is to induce conversion of the receptor protein to a biochemically functional form.
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