Yong Zhao

TL;DR: It is found that the miR-1 genes are direct transcriptional targets of muscle differentiation regulators including serum response factor, MyoD and Mef2, and a new algorithm for microRNA target identification that incorporates features of RNA structure and target accessibility is used.

TL;DR: It is shown that miRNA biogenesis in the mouse heart is essential for cardiogenesis, and targeted deletion of the muscle-specific miRNA, miR-1-2, revealed numerous functions in the heart, including regulation of cardiac morphogenesis, electrical conduction, and cell-cycle control.

TL;DR: Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis and future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNA.

TL;DR: It is found that mTOR induces MyoD-dependent miR-1 expression, leading to follistatin-mediated myocyte fusion, which in turn leads to programmed cell death and cell reprograming.

TL;DR: In this article, the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues, and different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on principal component analysis.