R
Robert McKenna
Researcher at University of Florida
Publications - 481
Citations - 23708
Robert McKenna is an academic researcher from University of Florida. The author has contributed to research in topics: Carbonic anhydrase & Carbonic anhydrase II. The author has an hindex of 78, co-authored 457 publications receiving 21349 citations. Previous affiliations of Robert McKenna include University of South Carolina & Florida State University College of Arts and Sciences.
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Journal ArticleDOI
Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)
TL;DR: This review covers the patents of medically relevant carbonic anhydrase inhibitors between 2011–2016 and highlights the need for isoform specific inhibitors to further improve isoform specificity and prevent sulfur allergies.
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The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
David M. Duda,Lakshmanan Govindasamy,Mavis Agbandje-McKenna,Chingkuang Tu,David N. Silverman,Robert McKenna +5 more
TL;DR: This structure presents the highest resolution structure of a carbonic anhydrase isozyme so far determined and adds to the understanding of proton-transfer processes.
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Structure of an Enteric Pathogen, Bovine Parvovirus
Shweta Kailasan,Sujata Halder,Brittney L. Gurda,Heather Bladek,Paul R. Chipman,Robert McKenna,Kevin M. Brown,Mavis Agbandje-McKenna +7 more
TL;DR: The high-resolution structure of the BPV capsid assembled from its predominant capsid protein VP2, known to be involved in a myriad of functions during host cell entry, pathogenesis, and antigenicity for other members of the Parvovirinae, is determined.
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Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.
TL;DR: Kinetic studies utilizing the measurement of (18)O-labeled CO2 by mass spectrometry revealed that dsHCAII retained high catalytic efficiency, and differential scanning calorimetry showed acid stability and thermal stability that was enhanced by up to 14 K compared with native HCAII.
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New approaches to the minimally invasive treatment of lung cancer.
Robert McKenna,Ward V. Houck +1 more
TL;DR: Current data suggest that, compared with a thoracotomy, video-assisted thoracoscopic surgery has advantages for anatomic pulmonary resections and complete anatomic resection and node dissections.