R
Robert McKenna
Researcher at University of Florida
Publications - 481
Citations - 23708
Robert McKenna is an academic researcher from University of Florida. The author has contributed to research in topics: Carbonic anhydrase & Carbonic anhydrase II. The author has an hindex of 78, co-authored 457 publications receiving 21349 citations. Previous affiliations of Robert McKenna include University of South Carolina & Florida State University College of Arts and Sciences.
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Journal ArticleDOI
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Albert A. Barrese,Caroli Genis,S. Zoë Fisher,Jared Orwenyo,Mudalige Thilak Kumara,Subodh K. Dutta,Eric Phillips,James J. Kiddle,Chingkuang Tu,David N. Silverman,Lakshmanan Govindasamy,Mavis Agbandje-McKenna,Robert McKenna,Brian C. Tripp +13 more
TL;DR: Thioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters, and may have advantages over sulfonamides in determining isozyme specificity.
Journal ArticleDOI
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases
Alessio Nocentini,Silvia Bua,Carrie L. Lomelino,Robert McKenna,Marta Menicatti,Gianluca Bartolucci,Barbara Tenci,Lorenzo Di Cesare Mannelli,Carla Ghelardini,Paola Gratteri,Claudiu T. Supuran +10 more
TL;DR: In vitro results suggest multiple mechanisms of action are responsible for the compounds' cytotoxic efficacy, and compounds endowed with the best hCA IX inhibitory efficacy were evaluated for antiproliferative activity against HT-29 colon cancer cell lines.
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Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells.
Zhijuan Chen,Lingbao Ai,Mam Y. Mboge,Chingkuang Tu,Robert McKenna,Kevin D. Brown,Coy D. Heldermon,Susan C. Frost +7 more
TL;DR: The data suggest that CAIX expression is associated with growth potentiation in the tumor graft model and in a TNBC line using knockdown strategies and blocking activity with an impermeant sulfonamide inhibitor, N-3500, and suggests that in the acidic microenvironment of tumors, CAIX plays a role in stabilizing pH at a value that favors cancer cell survival.
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Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Jose Clemente,Lakshmanan Govindasamy,Amrita Madabushi,S.Z. Fisher,Rebecca E. Moose,Charles A. Yowell,Koushi Hidaka,Tooru Kimura,Yoshio Hayashi,Yoshiaki Kiso,Mavis Agbandje-McKenna,John B. Dame,Ben M. Dunn,Robert McKenna +13 more
TL;DR: Inhibition analysis of PmPM4 suggests the potential for allophenylnorstatine-based compounds to be effective against all species of malaria infecting humans and for the future development of a broad-based inhibitor.
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Genomic evolution in a virus under specific selection for host recognition.
TL;DR: Results supported previous findings that evolving populations of small ssDNA viruses may maintain relatively high levels of genetic variation and suggested non-specific alterations to capsid structure could be an important component of adaptation to novel hosts.