R
Robert McKenna
Researcher at University of Florida
Publications - 481
Citations - 23708
Robert McKenna is an academic researcher from University of Florida. The author has contributed to research in topics: Carbonic anhydrase & Carbonic anhydrase II. The author has an hindex of 78, co-authored 457 publications receiving 21349 citations. Previous affiliations of Robert McKenna include University of South Carolina & Florida State University College of Arts and Sciences.
Papers
More filters
Journal ArticleDOI
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.
Nicolino Pala,Laura Micheletto,Mario Sechi,Mayank Aggarwal,Fabrizio Carta,Robert McKenna,Claudiu T. Supuran +6 more
TL;DR: A series of novel benzene- and 2,3,5,6-tetrafluorobenzenesulfonamide was synthesized by using a click chemistry approach starting from azido-substituted sulfonamides and alkynes, incorporating aryl, alkyl, cycloalkyl, and amino-/hydroxy-/halogenoalksyl moieties.
Journal ArticleDOI
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Alessio Nocentini,Mariangela Ceruso,Silvia Bua,Carrie L. Lomelino,Jacob T. Andring,Robert McKenna,Cecilia Lanzi,Silvia Sgambellone,Riccardo Pecori,Rosanna Matucci,Luca Filippi,Paola Gratteri,Fabrizio Carta,Emanuela Masini,Silvia Selleri,Claudiu T. Supuran +15 more
TL;DR: The reported evidence supports the proof-of-concept of β-ARs blocker-CAI hybrids for antiglaucoma therapy with an innovative mechanism of action.
Journal ArticleDOI
The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics
Xi Huang,Manuel D. Britto,Jamie L. Kear-Scott,Christopher D. Boone,James R. Rocca,Carlos Simmerling,Robert McKenna,Michael Bieri,Paul R. Gooley,Ben M. Dunn,Gail E. Fanucci +10 more
TL;DR: Both pulsed electron double resonance and NMR 15N relaxation measurements are utilized to characterize equilibrium conformational sampling and backbone dynamics of an HIV-1 protease construct containing four specific natural polymorphisms commonly found in subtypes A, F, and CRF_01 A/E.
Journal ArticleDOI
The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis
Brian P. Mahon,Avni Bhatt,Lilien Socorro,Jenna M. Driscoll,Cynthia Okoh,Carrie L. Lomelino,Mam Y. Mboge,Justin J. Kurian,Chingkuang Tu,Mavis Agbandje-McKenna,Susan C. Frost,Robert McKenna +11 more
TL;DR: Insights from this study suggest an understanding of hCA IX-c stability and activity in low-pH tumor microenvironments and may be applicable to determining pH-related effects on enzymes.
Journal ArticleDOI
Sequestration of Carbon Dioxide by the Hydrophobic Pocket of the Carbonic Anhydrases
John F. Domsic,Robert McKenna +1 more
TL;DR: A more precise location was determined via the crystal structure of CO(2) trapped in both wild-type (holo) and zinc-free (apo) HCA2, and this information can be extended to the beta and gamma class enzymes to help elucidate the binding mode of carbon dioxide in these enzymes.