R
Robert McKenna
Researcher at University of Florida
Publications - 481
Citations - 23708
Robert McKenna is an academic researcher from University of Florida. The author has contributed to research in topics: Carbonic anhydrase & Carbonic anhydrase II. The author has an hindex of 78, co-authored 457 publications receiving 21349 citations. Previous affiliations of Robert McKenna include University of South Carolina & Florida State University College of Arts and Sciences.
Papers
More filters
Journal ArticleDOI
Pseudomonas aeruginosa β-carbonic anhydrase, psCA1, is required for calcium deposition and contributes to virulence.
Shalaka R. Lotlikar,Biraj B. Kayastha,Daniela Vullo,Sharmily Khanam,Reygan E. Braga,A.B. Murray,Robert McKenna,Claudiu T. Supuran,Marianna A. Patrauchan +8 more
TL;DR: It is shown that the β-CA psCA1 in P. aeruginosa contributes to virulence likely by enabling calcium salt deposition, which can be partially controlled by inhibiting its catalytic activity.
Journal ArticleDOI
Thoracoscopic evaluation and treatment of pulmonary disease.
TL;DR: Only surgeons with the VATS skills that allow them to perform complex procedures should perform the procedure, and the completeness of the cancer surgery should not be compromised.
Journal ArticleDOI
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
Brian P. Mahon,Carrie L. Lomelino,Janina Ladwig,Gregory M. Rankin,Jenna M. Driscoll,Antonieta L. Salguero,Melissa A. Pinard,Daniela Vullo,Claudiu T. Supuran,Sally-Ann Poulsen,Robert McKenna +10 more
TL;DR: Five X-ray crystal structures are presented, determined to a resolution of 1.7 Å or better, of both hCA II (a ubiquitous CA) and an engineered hCA IX-mimic in complex with selected glucosyl sulfamates and structurally rationalize mechanisms for hCA VIII selectivity.
Journal ArticleDOI
Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function
TL;DR: The 1.6 Å resolution structure of an imidazole-based CA activator in complex with the ubiquitously-expressed human CA II is reported and a proposed mechanism of CA activation by the compound and its potential applications in the neurobiology of aging are discussed.
Journal ArticleDOI
Malignant monotypic epithelioid angiomyolipoma of the retroperitoneum.
TL;DR: This case represents the first description of metastatic disease occurring in an EAML of this particular site, composed exclusively of atypical epithelioid cells, which metastasized to the liver and the mediastinum.