R
Robert McKenna
Researcher at University of Florida
Publications - 481
Citations - 23708
Robert McKenna is an academic researcher from University of Florida. The author has contributed to research in topics: Carbonic anhydrase & Carbonic anhydrase II. The author has an hindex of 78, co-authored 457 publications receiving 21349 citations. Previous affiliations of Robert McKenna include University of South Carolina & Florida State University College of Arts and Sciences.
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Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies.
Yu-Shan Tseng,Kim Van Vliet,Lavanya Rao,Robert McKenna,Barry J. Byrne,Aravind Asokan,Mavis Agbandje-McKenna +6 more
TL;DR: A panel of six new mouse monoclonal antibodies (MAbs) has been generated against AAV8 and AAV9 capsids, two vectors being developed for therapeutic application and showed that these MAbs are capable of neutralizing virus infection.
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Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells
Elize Wolmarans,T.V. Mqoco,Andre Stander,Sandra D. Nkandeu,Katherine H. Sippel,Robert McKenna,Annie M. Joubert +6 more
TL;DR: It was demonstrated that ESE-16 induces cell death via both autophagy and apoptosis in esophageal carcinoma cells, paving the way for future investigation into the role of ESE -16 in ex vivo and in vivo studies as a possible anticancer agent.
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Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
TL;DR: Sulfonamide was a medium potency hCA I and II inhibitor but was highly effective as a hCA IX and XII inhibitor, which has been explained by resolving the crystal structure, and may be used to design more isoform-selective compounds.
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In-hospital clinical and economic consequences of pulmonary wedge resections for cancer using video-assisted thoracoscopic techniques vs traditional open resections: A retrospective database analysis
John A. Howington,Candace Gunnarsson,Michael A. Maddaus,Robert McKenna,Bryan F. Meyers,Daniel L. Miller,Matthew Moore,John A. Rizzo,Scott J. Swanson +8 more
TL;DR: Although this retrospective database analysis could not address the issue of oncologic outcome equivalence, a clear advantage of VATS over open wedge lung cancer resection was found for both acute clinical outcomes and hospital costs.
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Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition
TL;DR: Important differences of binding emerged, which explain the highly different inhibition profile of the two compounds against the investigated CA isoforms, most of which (CA I, II, IX and XII) are important drug targets.