Showing papers in "Current Opinion in Biotechnology in 2017"

TL;DR: There is evidence that these foods provide health benefits well-beyond the starting food materials, and increasingly understood that fermented foods can also have enhanced nutritional and functional properties due to transformation of substrates and formation of bioactive or bioavailable end-products.

TL;DR: Although currently overshadowed by MS in terms of numbers of compounds resolved, NMR spectroscopy offers advantages both on its own and coupled with MS, and is adept at tracing metabolic pathways and fluxes using isotope labels.

TL;DR: Analysis indicates potential for radically improved cost competitiveness and feasibility at smaller scale compared to current technology, arising from R&D-driven advances and configurational changes.

TL;DR: This work highlights the latest additions to the hemoprotein-catalyzed reaction repertoire (including carbene Si-H and C-H insertions, Doyle-Kirmse reactions, aldehyde olefinations, azide-to-aldehyde conversions, and intermolecular nitrene C- H insertion) and shows how different hemop protein scaffolds offer varied reactivity and selectivity.

TL;DR: Recent advances in systems metabolic engineering tools and strategies are reviewed together with accompanying application examples and how these tools and Strategies work together in simultaneous and synergistic ways to develop novel microbial cell factories are described.

TL;DR: This review examines the most recent update on the selection of aptamers for small molecules, the development and application of aptasensors in the detection of small molecule contaminants in environment and their applications to the real samples as environmental monitoring.

TL;DR: Strategies for muscle repair utilizing biomaterials that can provide signals to either transplanted or host muscle cells are described, which range from approaches that utilize biomMaterials alone to those that combine biommaterials with exogenous growth factors, ex vivo cultured cells, and extensive culture time.

TL;DR: This review presents the state of the art and the areas that need further experimentation in biofortification of plant-derived foods with provitamin A carotenoids, using transgenic approaches as well as conventional breeding.

TL;DR: Recent advances in searching techniques that are at the core of environmental monitoring strategies using autonomous vehicles are surveyed.

TL;DR: Concerns on potential risks to human health and the environment posed by use of engineered nanomaterials (ENMs) in food applications must be adequately evaluated at the developmental stage to ensure consumer's acceptance.

TL;DR: This review describes the current knowledge regarding iodine physiology in higher plants, and provides updates on recent agronomic and metabolic engineering strategies of biofortification.

TL;DR: In this review, it is described how recent advances in spatial transcriptomics open the way for tissue-level systems biology.

TL;DR: A comparison of different experimental techniques for corona formation of adsorbed proteins around nanoparticles is given and pros and contras of the different methods will be discussed.

TL;DR: DNAzymes, an emerging class of metal ion-dependent enzymes selective for almost any metal ion, have been functionalized with fluorophores, nanoparticles and other imaging agents and incorporated into sensors for the detection ofMetal ions in environmental samples and for imaging metal ions in living cells.

TL;DR: Matrix assisted laser desorption/ionization mass spectrometry imaging provides researchers with a new route to the discovery of potential biomarkers of human disease and elucidation of the underlying biology of metabolic regulation, thus bringing the understanding of human health to a new level.

TL;DR: In this review, the most recent and promising results that have contributed to increasing the iron content in different crops are highlighted and methods that to date have been used to reach iron biofortification goals are discussed.

TL;DR: Advances that significantly improved the performance of capillary electrophoresis-mass spectrometry are considered, with a special emphasis on the sheathless porous tip interface.

TL;DR: These emerging enzyme engineering platforms, which in some cases enable the screening of greater than 10 million enzyme variants, are discussed, and benefits and limitations of each technology are highlighted.

TL;DR: The metabolic engineering and nascent protein engineering strategies undertaken in each of these chassis to convert different feedstocks to adipic, muconic and glucaric acid are reviewed.

TL;DR: Clinical and public health communities are urged to be patient to allow human milk and lactation researchers to first understand what constitutes 'normal' in terms of the milk microbiome prior to jumping the gun to investigate if and how this important source of microbes impacts maternal and infant health.

TL;DR: This article offers a focused review of recent progress in nanotechnology-enabled biosensing as applied to foods and related matrices, paying particular attention to trends in the field, recent breakthroughs, and current areas of need.

TL;DR: Robust precursor supplies with optimized high-production hosts can also be used as an efficient platform to rapidly screen terpene cyclases and accelerate the process of mining new terpenoids.

TL;DR: This paper discusses emerging biological and biochemical means through which degradation of lignin to aromatic monomers can lead to the derivation of commercially valuable products.

TL;DR: The strategies developed in recent years for activating silent BGCs are described and broadly divided into two categories: approaches in native hosts and approaches in heterologous hosts.

TL;DR: In this article, the authors examined the evidence to date of the efficacy of iron-bio-fortified staple food crops on improving iron status in at-risk populations, including rice, pearl millet, and beans.

TL;DR: This review briefly summarizes recent advances in the field of fluorescent chemical protein labelling inside living cells and illustrates key aspects on the requirements and advantages of each given method.

TL;DR: Progress toward personalizing T cell-mediated immunotherapy for cancer as well as challenges going forward are discussed.

TL;DR: Modern methods for activity-based protein profiling-based chemoproteomic strategies to map 'ligandable' hotspots in proteomes using activity and reactivity-based chemical probes to allow for pharmacological interrogation of these previously difficult targets are discussed.

TL;DR: This review focuses on synthetic molecular nanostructures which self-assemble under dissipative conditions and the chemical function associated with the transient assemblies is operational as long as chemical fuel is present.

TL;DR: Advances in systems biology and metabolic engineering of yeast for improving recombinant protein production are reviewed.