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Roberta Tassinari
Researcher at Istituto Superiore di Sanità
Publications - 45
Citations - 877
Roberta Tassinari is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 11, co-authored 37 publications receiving 676 citations.
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Journal ArticleDOI
Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen
Roberta Tassinari,Francesco Cubadda,Gabriele Moracci,Federica Aureli,Marilena D'Amato,Mauro Valeri,Barbara De Berardis,Andrea Raggi,Alberto Mantovani,Daniele Passeri,Marco Rossi,Francesca Maranghi +11 more
TL;DR: In the spleen of treated animals TiO2 aggregates and increased white pulp were detected, even though Ti tissue levels remained low reflecting the low doses and the short exposure time, and prompted to comprehensively assess endocrine and reproductive effects in the safety evaluation of nanomaterials.
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Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in cd1 mice
Simona De Angelis,Roberta Tassinari,Francesca Maranghi,Agostino Eusepi,Antonio Di Virgilio,Flavia Chiarotti,Laura Ricceri,Aldina Venerosi Pesciolini,Enzo Gilardi,Gabriele Moracci,Gemma Calamandrei,Antonella Olivieri,Alberto Mantovani +12 more
TL;DR: For the first time these results indicate that CPF exposure at dose levels not inducing brain AchE inhibition causes thyroid alterations in dams and in F1 CD1 mice, suggesting thyroid may be a sensitive target to CPF developmental exposure possibly leading to long-term effects on thyroid function.
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Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice.
TL;DR: Placenta is considered as an important target of BPA, even at environmentally relevant dose levels, and transcriptomic analysis indicated that BPA05 promoted and BPA50 inhibited blood vessel development and branching.
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Short-term oral exposure to low doses of nano-sized TiO2 and potential modulatory effects on intestinal cells.
Maria Grazia Ammendolia,Francesca Iosi,Francesca Maranghi,Roberta Tassinari,Francesco Cubadda,Federica Aureli,Andrea Raggi,Fabiana Superti,Alberto Mantovani,Barbara De Berardis +9 more
TL;DR: Cell treatments with nanoparticles in association with testosterone or IGF-1 showed increased cell proliferation, compared to nanoparticles or testosterone/IGF-1 alone, and attention should be given to the potential modulating activity of this nanomaterial on cell proliferation.
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In vivo toxicity and genotoxicity of beauvericin and enniatins. Combined approach to study in vivo toxicity and genotoxicity of mycotoxins beauvericin (BEA) and enniatin B (ENNB)
Francesca Maranghi,Roberta Tassinari,Laura Narciso,Sabrina Tait,Cinzia La Rocca,Gabriella Di Felice,Cinzia Butteroni,Silvia Corinti,Bianca Barletta,Eugenia Cordelli,Francesca Pacchierotti,Patrizia Eleuteri,Paola Villani,Ludovic Le Hégarat,Valérie Fessard,Océane Reale +15 more
TL;DR: The results support a genotoxic effect in bone marrow and liver cells after acute treatment, but not after repeated exposure, and Immunotoxic ENNB effects were observed in both genders, suggestive of a suppressive/inhibiting activity particularly evident in males.