M
Mauro Valeri
Researcher at Istituto Superiore di Sanità
Publications - 15
Citations - 289
Mauro Valeri is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Biology & Haematopoiesis. The author has an hindex of 4, co-authored 10 publications receiving 211 citations.
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Journal ArticleDOI
Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen
Roberta Tassinari,Francesco Cubadda,Gabriele Moracci,Federica Aureli,Marilena D'Amato,Mauro Valeri,Barbara De Berardis,Andrea Raggi,Alberto Mantovani,Daniele Passeri,Marco Rossi,Francesca Maranghi +11 more
TL;DR: In the spleen of treated animals TiO2 aggregates and increased white pulp were detected, even though Ti tissue levels remained low reflecting the low doses and the short exposure time, and prompted to comprehensively assess endocrine and reproductive effects in the safety evaluation of nanomaterials.
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Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.
Anna Rita Migliaccio,Fabrizio Martelli,Maria Verrucci,Massimo Sanchez,Mauro Valeri,Giovanni Migliaccio,Alessandro M. Vannucchi,Maria Zingariello,Angela Di Baldassarre,Barbara Ghinassi,Rosa Alba Rana,Yvette van Hensbergen,Willem E. Fibbe +12 more
TL;DR: Analysis of the mechanism that rescues hematopoiesis in mice carrying the hypomorphic Gata1(low) mutation provides evidence that extramedullary microenvironments sustain maturation of stem cells that would be otherwise incapable of maturing in the marrow.
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Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stress.
Massimo Sanchez,Irving L. Weissman,Maria G. Pallavicini,Mauro Valeri,Paola Guglielmelli,Alessandro M. Vannucchi,Giovanni Migliaccio,Anna Rita Migliaccio,Anna Rita Migliaccio +8 more
TL;DR: Comparisons of the biological properties of MEP and PEM cells in marrow and spleen of mice with and without acute or chronic erythroid stress suggest that these cells represent distinct cell populations that may exist in an upstream‐downstream differentiation relationship under conditions of stress.
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Metabolic, reproductive and thyroid effects of bis(2-ethylhexyl) phthalate (DEHP) orally administered to male and female juvenile rats at dose levels derived from children biomonitoring study.
Roberta Tassinari,Sabrina Tait,Luca Busani,Andrea Martinelli,Laura Narciso,Mauro Valeri,Amalia Gastaldelli,Annalisa Deodati,Cinzia La Rocca,Francesca Maranghi +9 more
TL;DR: The results showed that main targets of DEHP during juvenile period were liver and metabolic system in both sexes, while sex-specific effects were recorded in reproductive system (male rats) and in thyroid (female rats).
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Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: A multitarget approach
Roberta Tassinari,Gabriella Di Felice,Cinzia Butteroni,Bianca Barletta,Silvia Corinti,Francesco Cubadda,Federica Aureli,Andrea Raggi,Laura Narciso,Sabrina Tait,Mauro Valeri,Andrea Martinelli,Antonio Di Virgilio,Francesca Pacchierotti,Eugenia Cordelli,Patrizia Eleuteri,Paola Villani,Valérie Fessard,Francesca Maranghi +18 more
TL;DR: The whole integrative study is presented here along with the results of dispersion characterization, tissue distribution, general toxicity, blood/serum biomarkers, histopathological and immunotoxicity endpoints, which provide new insight for a comprehensive risk assessment of SAS exposure by the oral route.