R
Robin Antrobus
Researcher at University of Cambridge
Publications - 89
Citations - 4125
Robin Antrobus is an academic researcher from University of Cambridge. The author has contributed to research in topics: Innate immune system & Human cytomegalovirus. The author has an hindex of 35, co-authored 83 publications receiving 3157 citations.
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Journal ArticleDOI
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare,Yoko Ito,Tae-Won Kang,Michael P. Weekes,Nicholas J Matheson,Daniel A. Patten,Shishir Shetty,Aled Parry,Suraj Menon,Rafik Salama,Robin Antrobus,Kosuke Tomimatsu,William J. Howat,Paul J. Lehner,Lars Zender,Masashi Narita +15 more
TL;DR: It is shown that the dynamic alteration of NOTCH1 activity during senescence dictates a functional balance between these two distinct secretomes: one representing TGF-β and the other pro-inflammatory cytokines, highlighting that NotCH1 is a temporospatial controller of secretome composition.
Journal ArticleDOI
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
Iva A. Tchasovnikarova,Richard T. Timms,Nicholas J Matheson,Kim Wals,Robin Antrobus,Berthold Göttgens,Gordon Dougan,Mark A. Dawson,Paul J. Lehner +8 more
TL;DR: A nonlethal forward genetic screen in near-haploid KBM7 cells identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans.
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Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef
Nicholas J Matheson,Jonathan Sumner,Kim Wals,Radu Rapiteanu,Michael P. Weekes,Raphael Vigan,Julia Weinelt,Michael Schindler,Robin Antrobus,Ana S. H. Costa,Christian Frezza,Clary B. Clish,Stuart J. D. Neil,Paul J. Lehner +13 more
TL;DR: This work took a distinct, systems-level, quantitative proteomic approach to gain a comprehensive, unbiased overview of how HIV infection remodels the T cell surface, and defined a unique paradigm of HIV interference with immunometabolism.
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Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles
Georg H. H. Borner,Robin Antrobus,Jennifer Hirst,Gary S. Bhumbra,Patrycja Kozik,Lauren P. Jackson,Daniela A. Sahlender,Margaret S. Robinson +7 more
TL;DR: A multivariate proteomics approach identified numerous new clathrin-coated vesicle proteins as well as the first AP-4 accessory protein, and also revealed how auxilin depletion causes mitotic arrest through sequestration of spindle proteins inClathrin cages.
Journal ArticleDOI
Role for the obesity-related FTO gene in the cellular sensing of amino acids
Pawan Gulati,Man Ka Cheung,Robin Antrobus,Chris Church,Heather P. Harding,Yi-Chun Loraine Tung,Debra Rimmington,Marcella Ma,David Ron,Paul J. Lehner,Frances M. Ashcroft,Roger D. Cox,Anthony P. Coll,Stephen O'Rahilly,Giles S.H. Yeo +14 more
TL;DR: A role for FTO is described in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling, suggesting that FTO may influence body composition through playing a role in cellular nutrient sensing.