S
S Y Clark
Researcher at Wellcome Trust Sanger Institute
Publications - 5
Citations - 1358
S Y Clark is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Chromosome 19 & Chromosome 21. The author has an hindex of 5, co-authored 5 publications receiving 1293 citations.
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Journal ArticleDOI
DNA sequence and analysis of human chromosome 9
Andrew J. Mungall,Sophie Palmer,Sarah Sims,C A Edwards,Jennifer L. Ashurst,Laurens G. Wilming,Matthew Jones,Roger Horton,Sarah E. Hunt,Carol Scott,James G. R. Gilbert,Michele Clamp,Graeme Bethel,Sarah Milne,R Ainscough,J P Almeida,K D Ambrose,T D Andrews,R I S Ashwell,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,Darren Barker,K F Barlow,K Bates,David Beare,Helen Beasley,O. Beasley,Christine P. Bird,S. Blakey,S Bray-Allen,J Brook,A J Brown,J Y Brown,D C Burford,W Burrill,John Burton,C Carder,Nigel P. Carter,J C Chapman,S Y Clark,Graeme T Clark,C M Clee,S. M. Clegg,V. Cobley,R. E. Collier,Joanna Collins,L K Colman,N Corby,G. J. Coville,K M Culley,Pawandeep Dhami,Jim Davies,Matthew Dunn,M Earthrowl,A E Ellington,K A Evans,L M Faulkner,Matthew D. Francis,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,Mohammed J. R. Ghori,L M Gilby,Christopher J. Gillson,Rebecca Glithero,Darren Grafham,M Grant,Susan M. Gribble,C Griffiths,Mark Griffiths,Rebekah Hall,K S Halls,S Hammond,Joanna Harley,E. Hart,Paul Heath,R Heathcott,S. Holmes,Philip Howden,Kevin L. Howe,Gareth R. Howell,Elizabeth J. Huckle,Sean Humphray,Matthew Humphries,Adrienne Hunt,Christopher M. Johnson,A Joy,M. Kay,Stephen Keenan,A M Kimberley,A. King,Gavin K. Laird,Cordelia Langford,S Lawlor,Daniel Leongamornlert,Margaret A. Leversha,Christine Lloyd,D. M. Lloyd,Jane E. Loveland,J Lovell,Sancha Martin,M Mashreghi-Mohammadi,Gareth Maslen,Lucy Matthews,O. T. McCann,S J McLaren,Kirsten McLay,Amanda McMurray,M. J F Moore,James C. Mullikin,David Niblett,T Nickerson,K L Novik,Karen Oliver,E K Overton-Larty,Anne Parker,R Patel,A. V. Pearce,A I Peck,Benjamin Phillimore,Sam Phillips,Robert W. Plumb,K M Porter,Y. Ramsey,S A Ranby,Catherine M. Rice,Mark T. Ross,S. Searle,Harminder Sehra,E Sheridan,C. D. Skuce,Sarah E. Smith,Michelle Smith,L Spraggon,S. Squares,Charles A. Steward,N Sycamore,G Tamlyn-Hall,J Tester,A J Theaker,Duncan W. Thomas,A Thorpe,Alan Tracey,A Tromans,B Tubby,Melanie M. Wall,J. M. Wallis,Anthony P. West,S S White,S. Whitehead,H Whittaker,A Wild,Dave Willey,T. E. Wilmer,Jonathan Wood,Paul Wray,J C Wyatt,L Young,R M Younger,David R. Bentley,Alan Coulson,Richard Durbin,Tim Hubbard,John Sulston,Ian Dunham,Jane Rogers,Stephan Beck +170 more
TL;DR: Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block, and detects recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection.
Journal ArticleDOI
The DNA sequence and comparative analysis of human chromosome 20.
Panos Deloukas,M Earthrowl,Darren Grafham,Marc Rubenfield,Lisa French,Charles A. Steward,Sarah Sims,Matthew Jones,S. Searle,Carol Scott,Kerstin Howe,Sarah E. Hunt,T D Andrews,James G. R. Gilbert,David Swarbreck,Jennifer L. Ashurst,A Taylor,J Battles,Christine P. Bird,R Ainscough,J P Almeida,R I S Ashwell,K D Ambrose,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,K Bates,Helen Beasley,S Bray-Allen,A J Brown,J Y Brown,D C Burford,W Burrill,John Burton,Patrick Cahill,D Camire,Nigel P. Carter,J C Chapman,S Y Clark,G Clarke,C M Clee,S. M. Clegg,N Corby,Alan Coulson,Pawandeep Dhami,I Dutta,Matthew Dunn,L M Faulkner,Adam Frankish,J Frankland,P Garner,J Garnett,Susan M. Gribble,C Griffiths,Russell J. Grocock,Erik Gustafson,S Hammond,Joanna Harley,E. Hart,Paul Heath,T P Ho,B Hopkins,J Horne,Philip Howden,Elizabeth J. Huckle,C Hynds,Chris Johnson,David W. Johnson,A Kana,M. Kay,A M Kimberley,J K Kershaw,M Kokkinaki,Gavin K. Laird,S Lawlor,H M Lee,Daniel Leongamornlert,G Laird,Christine Lloyd,D. M. Lloyd,Jane E. Loveland,J Lovell,Stuart McLaren,Kirsten McLay,Amanda McMurray,M Mashreghi-Mohammadi,Lucy Matthews,Sarah Milne,T Nickerson,M Nguyen,E K Overton-Larty,Sophie Palmer,A. V. Pearce,A I Peck,Sarah Pelan,Benjamin Phillimore,K M Porter,Catherine M. Rice,A Rogosin,Mark T. Ross,Theologia Sarafidou,Harminder Sehra,Ratna Shownkeen,C. D. Skuce,Michelle Smith,L Standring,N Sycamore,J Tester,A Thorpe,W Torcasso,Alan Tracey,A Tromans,J Tsolas,Melanie M. Wall,J Walsh,H Wang,Keith Weinstock,Anthony P. West,David Willey,S. Whitehead,Laurens G. Wilming,Paul Wray,L Young,Yuan Chen,Ruth C. Lovering,Nicholas K. Moschonas,Reiner Siebert,Kim Fechtel,David Bentley,Richard Durbin,Tim Hubbard,Lynn Doucette-Stamm,Stephan Beck,Douglas Smith,Jane Rogers +135 more
TL;DR: Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.
Journal ArticleDOI
The DNA sequence and biological annotation of human chromosome 1
Simon G. Gregory,Simon G. Gregory,K F Barlow,Kirsten McLay,Rajinder Kaul,David Swarbreck,Andrew Dunham,Carol Scott,Kevin L. Howe,Kathryn Woodfine,Chris C. A. Spencer,Matthew Jones,Christopher J. Gillson,S. Searle,Yi Zhou,Felix Kokocinski,L McDonald,R Evans,Katharine A. Phillips,A Atkinson,R Cooper,C Jones,R. E. Hall,T D Andrews,Christine Lloyd,R Ainscough,J P Almeida,K D Ambrose,F Anderson,R. W. Andrew,R I S Ashwell,K Aubin,A K Babbage,C L Bagguley,J Bailey,Helen Beasley,Graeme Bethel,Christine P. Bird,S Bray-Allen,J Y Brown,A J Brown,D. Buckley,John Burton,Jacqueline M. Bye,C Carder,J C Chapman,S Y Clark,G Clarke,C M Clee,V. Cobley,R. E. Collier,N Corby,G. J. Coville,Jim Davies,Rebecca Deadman,Matthew Dunn,M Earthrowl,A. G. Ellington,H Errington,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,M. R J Ghori,Richard Gibson,L M Gilby,Will Gillett,Rebecca Glithero,Darren Grafham,C Griffiths,Sam Griffiths-Jones,Russell J. Grocock,S Hammond,Elliot Harrison,E. Hart,Eric Haugen,Paul Heath,S. Holmes,Kathryn E. Holt,Philip Howden,Adrienne Hunt,Sarah E. Hunt,G Hunter,J Isherwood,R. James,Chris Johnson,D. Johnson,A Joy,M. Kay,J K Kershaw,M. Kibukawa,A M Kimberley,A. King,Andrew J Knights,Heena V. Lad,Gavin K. Laird,S Lawlor,Daniel Leongamornlert,D. M. Lloyd,Jane E. Loveland,J Lovell,Michael J. Lush,Rachel Lyne,Sancha Martin,M Mashreghi-Mohammadi,Lucy Matthews,Nicholas Matthews,Stuart McLaren,Sarah Milne,S. Mistry,M. J F Moore,T Nickerson,C. Odell,Karen Oliver,A. Palmeiri,Sophie Palmer,Anne Parker,D. Patel,A. V. Pearce,A I Peck,Sarah Pelan,Karen A. Phelps,Benjamin Phillimore,Robert W. Plumb,Jeena Rajan,Charles F. Raymond,Greg W. Rouse,Channakhone Saenphimmachak,Harminder Sehra,E Sheridan,Ratna Shownkeen,Sarah Sims,C. D. Skuce,Michelle Smith,Charles A. Steward,Sankaran Subramanian,N Sycamore,Alan Tracey,A Tromans,Z. Van Helmond,Melanie M. Wall,J. M. Wallis,Simon D. M. White,S. Whitehead,Jane E. Wilkinson,David Willey,H. Williams,Laurens G. Wilming,Paul Wray,Z. Wu,Alan Coulson,M. Vaudin,John Sulston,Richard Durbin,Tim Hubbard,Richard Wooster,Ian Dunham,Nigel P. Carter,G. McVean,Mark T. Ross,Jennifer Harrow,Maynard V. Olson,Stephan Beck,Jane Rogers,David R. Bentley +165 more
TL;DR: The finished sequence and biological annotation of human chromosome 1 is reported, which reveals patterns of sequence variation that reveal signals of recent selection in specific genes that may contribute to human fitness, and also in regions where no function is evident.
Journal ArticleDOI
Erratum: The DNA sequence and biological annotation of human chromosome 1 (Nature (2006) 441 (315-321))
Simon G. Gregory,K F Barlow,Kirsten McLay,R Kaul,David Swarbreck,Andrew Dunham,Carol Scott,Kerstin Howe,K Woodfine,Spencer Cca.,Matthew Jones,Christopher J. Gillson,S. Searle,Y Zhou,Felix Kokocinski,L McDonald,R Evans,Katharine A. Phillips,A Atkinson,R Cooper,C Jones,Rebekah Hall,T D Andrews,Christine Lloyd,R Ainscough,J P Almeida,K D Ambrose,F Anderson,R. W. Andrew,Ashwell Ris.,K Aubin,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,Helen Beasley,Graeme Bethel,Christine P. Bird,S Bray-Allen,J Y Brown,A J Brown,S P Bryant,D Buckley,D C Burford,Burrill Wdh.,John Burton,Jacqueline M. Bye,C Carder,J C Chapman,S Y Clark,G Clarke,C M Clee,S. M. Clegg,V. Cobley,R. E. Collier,N Corby,G. J. Coville,Joy Davies,Rebecca Deadman,Pawandeep Dhami,Oliver M. Dovey,Matthew Dunn,M Earthrowl,A. G. Ellington,H Errington,L M Faulkner,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,Ghori Mrj.,Richard Gibson,L M Gilby,W Gillett,Rebecca Glithero,Darren Grafham,Susan M. Gribble,C Griffiths,Sam Griffiths-Jones,Russell J. Grocock,S Hammond,Harrison Esi.,E. Hart,E Haugen,Paul Heath,S. Holmes,Kathryn E. Holt,Philip Howden,Adrienne Hunt,Sarah E. Hunt,G Hunter,J Isherwood,R James,Chris Johnson,David H. Johnson,A Joy,M. Kay,J K Kershaw +98 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.
Journal Article
The DNA sequence and biological annotation of human chromosome 1 (vol 441, pg 315, 2006)
Simon G. Gregory,K F Barlow,Kirsten McLay,Rajinder Kaul,David Swarbreck,Andrew Dunham,Carol Scott,Kerstin Howe,Kathryn Woodfine,Cca Spencer,Matthew Jones,Christopher J. Gillson,S. Searle,Yi Zhou,Felix Kokocinski,L McDonald,R Evans,Katharine A. Phillips,A Atkinson,R Cooper,C Jones,Rebekah Hall,T D Andrews,Christine Lloyd,R Ainscough,J P Almeida,K D Ambrose,F Anderson,R. W. Andrew,Ris Ashwell,K Aubin,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,Helen Beasley,Graeme Bethel,Christine P. Bird,S Bray-Allen,J Y Brown,A J Brown,S P Bryant,D Buckley,D C Burford,Wdh Burrill,John Burton,Jacqueline M. Bye,C Carder,J C Chapman,S Y Clark,G Clarke,C M Clee,S. M. Clegg,Cobley,R. E. Collier,N Corby,G. J. Coville,Joy Davies,Rebecca Deadman,Pawandeep Dhami,Oliver M. Dovey,Matthew Dunn,M Earthrowl,A. G. Ellington,H Errington,L M Faulkner,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,Mrj Ghori,Richard Gibson,L M Gilby,Will Gillett,Rebecca Glithero,Darren Grafham,Susan M. Gribble,C Griffiths,Sam Griffiths-Jones,Russell J. Grocock,S Hammond,Esi Harrison,E. Hart,Eric Haugen,Paul Heath,S. Holmes,Kathryn E. Holt,Philip Howden,Adrienne Hunt,Sarah E. Hunt,G Hunter,J Isherwood,R. James,Chris Johnson,D. Johnson,A Joy,M. Kay,J K Kershaw,M. Kibukawa,A M Kimberley,A. King,Andrew J Knights,Heena V. Lad,Gavin K. Laird,Cordelia Langford,S Lawlor,Daniel Leongamornlert,D. M. Lloyd,Jane E. Loveland,J Lovell,Michael J. Lush,Rachel Lyne,Sancha Martin,M Mashreghi-Mohammadi,Lucy Matthews,Nsw Matthews,Stuart McLaren,Sarah Milne,S. Mistry,Mjf Moore,T Nickerson,C. Odell,Karen Oliver,A. Palmeiri,Sophie Palmer,Richard Pandian,Anne Parker,D. Patel,A. V. Pearce,A I Peck,Sarah Pelan,Karen A. Phelps,Benjamin Phillimore,Robert W. Plumb,K M Porter,E Prigmore,Jeena Rajan,Charles F. Raymond,Greg W. Rouse,Channakhone Saenphimmachak,Harminder Sehra,E Sheridan,Ratna Shownkeen,Sarah Sims,C. D. Skuce,Michelle Smith,Charles A. Steward,Sankaran Subramanian,N Sycamore,Alan Tracey,A Tromans,Z. Van Helmond,Mwjm Wallis,Simon D. M. White,S. Whitehead,Jane E. Wilkinson,David Willey,H. Williams,Laurens G. Wilming,Paul Wray,Z. Wu,Alan Coulson,M. Vaudin,John Sulston,Richard Durbin,Tim Hubbard,Richard Wooster,Ian Dunham,Nigel P. Carter,G. McVean,Mark T. Ross,Jen Harrow,Maynard V. Olson,Stephan Beck,Jane Rogers,Bentley +176 more