E
E. Hart
Researcher at Wellcome Trust Sanger Institute
Publications - 14
Citations - 4344
E. Hart is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Sequence analysis & Chromosome 19. The author has an hindex of 14, co-authored 14 publications receiving 4082 citations.
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Journal ArticleDOI
The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
Christine G. Elsik,Christine G. Elsik,Christine G. Elsik,Ross L. Tellam,Kim C. Worley,Kim C. Worley,Richard A. Gibbs,Donna M. Muzny,George M. Weinstock,George M. Weinstock,David L. Adelson,Evan E. Eichler,Evan E. Eichler,Laura Elnitski,Roderic Guigó,Debora L. Hamernik,Steve M. Kappes,Harris A. Lewin,David J. Lynn,Frank W. Nicholas,Alexandre Reymond,Monique Rijnkels,Loren C. Skow,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Lawrence B. Schook,James E. Womack,Tyler Alioto,Stylianos E. Antonarakis,Alex Astashyn,Charles E. Chappie,Hsiu Chuan Chen,Jacqueline Chrast,Francisco Câmara,Olga Ermolaeva,Charlotte N. Henrichsen,Wratko Hlavina,Yuri Kapustin,Boris Kiryutin,Paul Kitts,Felix Kokocinski,Melissa J. Landrum,Donna Maglott,Kim D. Pruitt,Victor Sapojnikov,Stephen M. J. Searle,Victor V. Solovyev,Alexandre Souvorov,Catherine Ucla,Carine Wyss,Juan Manuel Anzola,Daniel Gerlach,Daniel Gerlach,Eran Elhaik,Eran Elhaik,Dan Graur,Justin T. Reese,Robert C. Edgar,John C. McEwan,Gemma Marie Payne,Joy M. Raison,Thomas Junier,Thomas Junier,Evgenia V. Kriventseva,Eduardo Eyras,Mireya Plass,Ravikiran Donthu,Denis M. Larkin,James M. Reecy,Mary Qu Yang,Lin Chen,Ze Cheng,Carol G. Chitko-McKown,George E. Liu,Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,Jiuzhou Song,Bin Zhu,Daniel G. Bradley,Fiona S. L. Brinkman,Lilian P.L. Lau,Matthew D. Whiteside,Angela K. Walker,Thomas T. Wheeler,Theresa Casey,J. Bruce German,J. Bruce German,Danielle G. Lemay,Nauman J. Maqbool,A.J. Molenaar,Seongwon Seo,Paul Stothard,Cynthia L. Baldwin,R. Baxter,Candice L. Brinkmeyer-Larigford,Wendy C. Brown,Christopher P. Childers,Timothy Connelley,Shirley A. Ellis,Krista L. Fritz,Elizabeth Glass,Carolyn T.A. Herzig,Antti Livanainen,Kevin K. Lahmers,Anna K. Bennett,C. Michael Dickens,James G. R. Gilbert,Darren E. Hagen,Hanni Salih,Jan Aerts,Alexandre Rodrigues Caetano,Brian P. Dalrymple,José Fernando Garcia,Clare A. Gill,Stefan Hiendleder,Erdogan Memili,D.M. Spurlock,John L. Williams,Lee Alexander,Michael J. Brownstein,Le Luo Guan,Robert A. Holt,Steven J.M. Jones,Marco A. Marra,Richard A. Moore,Stephen S. Moore,Andrew J. Roberts,Masaaki Taniguchi,Masaaki Taniguchi,Richard C. Waterman,Joseph Chacko,Mimi M. Chandrabose,Andy Cree,Marvin Diep Dao,Huyen Dinh,Ramatu Ayiesha Gabisi,Sandra Hines,Jennifer Hume,Shalini N. Jhangiani,Vandita Joshi,Christie Kovar,Lora Lewis,Yin Shin Liu,John Lopez,Margaret Morgan,Ngoc Nguyen,Geoffrey Okwuonu,San Juana Ruiz,Jireh Santibanez,Rita A. Wright,Christian J. Buhay,Yan Ding,Shannon Dugan-Rocha,Judith Herdandez,Michael Holder,Aniko Sabo,Amy Egan,Jason Goodell,Katarzyna Wilczek-Boney,Gerald R. Fowler,Matthew Hitchens,Ryan J. Lozado,Charles Moen,David Steffen,James T. Warren,Jingkun Zhang,Readman Chiu,Jacqueline E. Schein,K. James Durbin,K. James Durbin,Paul Havlak,Paul Havlak,Huaiyang Jiang,Yue Liu,Xiang Qin,Yanru Ren,Yufeng Shen,Yufeng Shen,Henry Song,Stephanie Bell,Clay Davis,Angela Jolivet Johnson,Sandra L. Lee,Lynne V. Nazareth,Bella Mayurkumar Patel,Ling Ling Pu,Selina Vattathil,Rex Lee Williams,Stacey M. Curry,Cerissa Hamilton,Erica Sodergren,Erica Sodergren,David A. Wheeler,Wes Barris,Gary L. Bennett,André Eggen,Ronnie D. Green,Gregory P. Harhay,Matthew Hobbs,Oliver C. Jann,John W. Keele,Matthew Peter Kent,Sigbjam Lien,Stephanie D. McKay,Sean McWilliam,Abhirami Ratnakumar,Robert D. Schnabel,Timothy P. L. Smith,Warren M. Snelling,Tad S. Sonstegard,Roger T. Stone,Yoshikazu Sugimoto,Akiko Takasuga,Jeremy F. Taylor,Curtis P. Van Tassell,Michael D. MacNeil,A.R.R. Abatepaulo,Colette A. Abbey,Virpi Ahola,Lassudara G. Almeida,Ariel Fernando Amadio,Elen Anatriello,Suria M. Bahadue,Fernando H. Biase,Clayton R. Boldt,Jeffery A. Carroll,W. A. Carvalho,Eliane P. Cervelatti,Elsa Chacko,Jennifer E. Chapin,Ye Cheng,Jung-Woo Choi,Adam J. Colley,Tatiana A. DeCampos,Marcos De Donato,Isabel Kinney Ferreira de Miranda Santos,Carlo José Freire de Oliveira,Heather M Deobald,Eve Devinoy,Kaitlin E. Donohue,Peter Dove,Annett Eberlein,Carolyn Fitzsimmons,Alessandra Mara Franzin,Gustavo Garcia,Sem Genini,Cody J. Gladney,Jason R. Grant,Marion L. Greaser,Jonathan A. Green,Darryl L. Hadsell,Hatam A. Hakimov,Rob Halgren,Jennifer Harrow,E. Hart,N. Hastings,Marta Hernández,Zhi-Liang Hu,Antti Iivanainen,Aaron Ingham,Terhi Iso-Touru,Catherine Jamis,Kirsty Jensen,Dimos Kapetis,Tovah Kerr,Sari S. Khalil,Hasan Khatib,D. Kolbehdari,D. Kolbehdari,Cham G. Kumar,Dinesh Kumar,Richard J. Leach,Justin C. Lee,Changxi Li,Krystin M. Logan,Roberto Malinverni,E. Marques,William F. Martin,Natália F. Martins,Sandra Regina Maruyama,Raffaele Mazza,Kim L. McLean,Juan F. Medrano,Barbara T. Moreno,Daniela D. Moré,Carl T. Muntean,Hari Prasad Nandakumar,Marcelo Fábio Gouveia Nogueira,Ingrid Olsaker,Sameer D. Pant,Francesca Panzitta,Rosemeire Conceição Parra Pastor,Mario Andres Poli,Nathan Poslusny,Satyanarayana Rachagani,Shoba Ranganathan,Shoba Ranganathan,Andrej Razpet,Penny K. Riggs,Gonzalo Rincon,Nelida Rodriguez-Osorio,Nelida Rodriguez-Osorio,Sandra L. Rodriguez-Zas,Natasha E. Romero,Anne G. Rosenwald,Lillian Sando,Sheila M. Schmutz,Libing Shen,Laura Sherman,Bruce R. Southey,Ylva Strandberg Lutzow,Jonathan V. Sweedler,Imke Tammen,Bhanu Prakash V.L. Telugu,Jennifer M. Urbanski,Yuri Tani Utsunomiya,Chris P. Verschoor,Ashley J. Waardenberg,Zhiquan Wang,Robert Ward,Rosemarie Weikard,Thomas H. Welsh,Stephen N. White,Stephen N. White,Laurens G. Wilming,Kris R. Wunderlich,Jianqi Yang,Feng-Qi Zhao +328 more
TL;DR: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage and provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Journal ArticleDOI
The DNA sequence of the human X chromosome
Mark T. Ross,Darren Grafham,Alison J. Coffey,Steven E. Scherer,Kirsten McLay,Donna M. Muzny,Matthias Platzer,Gareth R. Howell,Christine Burrows,Christine P. Bird,Adam Frankish,Frances L Lovell,Kevin L. Howe,Jennifer L. Ashurst,Robert S. Fulton,Ralf Sudbrak,Ralf Sudbrak,Gaiping Wen,Matthew C. Jones,Matthew E. Hurles,T. Daniel Andrews,Carol Scott,Stephen M. J. Searle,Juliane Ramser,Adam Whittaker,Rebecca Deadman,Nigel P. Carter,Sarah E. Hunt,Rui Chen,Andrew Cree,Preethi H. Gunaratne,Paul Havlak,Anne Hodgson,Michael L. Metzker,Stephen Richards,Graham Scott,David Steffen,Erica Sodergren,David A. Wheeler,Kim C. Worley,R Ainscough,K D Ambrose,M. Ali Ansari-Lari,Swaroop Aradhya,R I S Ashwell,A K Babbage,Claire L Bagguley,Andrea Ballabio,Ruby Banerjee,Gary E Barker,K F Barlow,Ian P. Barrett,Karen N Bates,David Beare,Helen Beasley,Oliver Beasley,Alfred Beck,Graeme Bethel,Karin Blechschmidt,Nicola Brady,Sarah Bray-Allen,Anne Bridgeman,Andrew Brown,Mary J. Brown,David Bonnin,Elspeth A. Bruford,Christian J. Buhay,Paula E. Burch,D C Burford,Joanne Burgess,Wayne Burrill,John Burton,Jackie Bye,C Carder,Laura Carrel,Joseph Chako,Joanne C Chapman,Dean Chavez,Ellson Y. Chen,Guan Chen,Yuan Chen,Zhijian J. Chen,Craig Chinault,Alfredo Ciccodicola,Sue Y Clark,Graham Clarke,Chris Clee,S. M. Clegg,Kerstin P. Clerc-Blankenburg,Karen Clifford,Vicky Cobley,Charlotte G. Cole,Jen S. Conquer,N Corby,Richard E Connor,Robert G. David,Joy Davies,Clay Davis,John M. Davis,Oliver Delgado,Denise R. DeShazo,Pawandeep Dhami,Yan Ding,Huyen Dinh,Steve Dodsworth,Heather R. Draper,Shannon Dugan-Rocha,Andrew Dunham,Matthew Dunn,K. James Durbin,Ireena Dutta,Tamsin Eades,Matthew Ellwood,Alexandra Emery-Cohen,Helen Errington,Kathryn L. Evans,Louisa Faulkner,Fiona Francis,John Frankland,Audrey Fraser,Petra Galgoczy,James G. R. Gilbert,Rachel Gill,Gernot Glöckner,Simon G. Gregory,Susan M. Gribble,C Griffiths,Russell J. Grocock,Yanghong Gu,Rhian Gwilliam,Cerissa Hamilton,E. Hart,Alicia Hawes,Paul Heath,Katja Heitmann,Steffen Hennig,Judith Hernandez,Bernd Hinzmann,Sarah Ho,Michael Hoffs,Phillip J Howden,Elizabeth J. Huckle,Jennifer Hume,Paul Hunt,Adrienne Hunt,Judith Isherwood,Leni S. Jacob,David W. Johnson,Sally Jones,Pieter J. de Jong,Shirin S. Joseph,Stephen Keenan,Susan H. Kelly,Joanne K Kershaw,Ziad Khan,Petra Kioschis,Sven Klages,Andrew J Knights,Anna Kosiura,Christie Kovar-Smith,Gavin K. Laird,Cordelia Langford,S Lawlor,Margaret A. Leversha,Lora Lewis,Wen Liu,Christine Lloyd,D. M. Lloyd,Hermela Loulseged,Jane E. Loveland,J Lovell,Ryan J. Lozado,Jing Lu,Rachael Lyne,Jie Ma,Manjula Maheshwari,Lucy Matthews,Jennifer McDowall,Stuart McLaren,Amanda McMurray,Patrick Meidl,Thomas Meitinger,Sarah Milne,George Miner,Shailesh L Mistry,Margaret Morgan,Sidney Morris,Ines Müller,James C. Mullikin,Ngoc Nguyen,Gabriele Nordsiek,Gerald Nyakatura,Christopher N O'Dell,Geoffery Okwuonu,Sophie Palmer,Richard Pandian,David Parker,Julia E. Parrish,Shiran Pasternak,Dina Patel,Alex V Pearce,D. Pearson,Sarah Pelan,Lesette Perez,K M Porter,Yvonne Ramsey,Kathrin Reichwald,Susan Rhodes,Kerry A Ridler,David Schlessinger,Mary G. Schueler,Harminder Sehra,Charles Shaw-Smith,Hua Shen,E Sheridan,Ratna Shownkeen,C. D. Skuce,Michelle Smith,Elizabeth C. Sotheran,Helen E. Steingruber,Charles A. Steward,Roy Storey,R Mark Swann,David Swarbreck,Paul E. Tabor,Stefan Taudien,Tineace Taylor,Brian Teague,Karen Thomas,Andrea Thorpe,Kirsten M. Timms,Alan Tracey,Steve Trevanion,A Tromans,Michele D'Urso,Daniel Verduzco,Donna Villasana,Lenee Waldron,Melanie M. Wall,Qiaoyan Wang,James T. Warren,Georgina Warry,Xuehong Wei,Anthony P. West,S. Whitehead,Mathew N Whiteley,Jane E. Wilkinson,David Willey,Gabrielle Williams,Leanne Williams,Angela Williamson,Helen Williamson,Laurens G. Wilming,Rebecca Woodmansey,Paul Wray,Jennifer Yen,Jingkun Zhang,Jianling Zhou,Huda Y. Zoghbi,Sara Zorilla,David Buck,Richard Reinhardt,Annemarie Poustka,André Rosenthal,Hans Lehrach,Alfons Meindl,Patrick Minx,LaDeana W. Hillier,Huntington F. Willard,Richard K. Wilson,Robert H. Waterston,Catherine M. Rice,M. Vaudin,Alan Coulson,David L. Nelson,George M. Weinstock,John Sulston,Richard Durbin,Tim Hubbard,Richard A. Gibbs,Stephan Beck,Jane Rogers,David R. Bentley +282 more
TL;DR: This analysis illustrates the autosomal origin of the mammalian sex chromosomes, the stepwise process that led to the progressive loss of recombination between X and Y, and the extent of subsequent degradation of the Y chromosome.
Journal ArticleDOI
DNA sequence and analysis of human chromosome 9
Andrew J. Mungall,Sophie Palmer,Sarah Sims,C A Edwards,Jennifer L. Ashurst,Laurens G. Wilming,Matthew Jones,Roger Horton,Sarah E. Hunt,Carol Scott,James G. R. Gilbert,Michele Clamp,Graeme Bethel,Sarah Milne,R Ainscough,J P Almeida,K D Ambrose,T D Andrews,R I S Ashwell,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,Darren Barker,K F Barlow,K Bates,David Beare,Helen Beasley,O. Beasley,Christine P. Bird,S. Blakey,S Bray-Allen,J Brook,A J Brown,J Y Brown,D C Burford,W Burrill,John Burton,C Carder,Nigel P. Carter,J C Chapman,S Y Clark,Graeme T Clark,C M Clee,S. M. Clegg,V. Cobley,R. E. Collier,Joanna Collins,L K Colman,N Corby,G. J. Coville,K M Culley,Pawandeep Dhami,Jim Davies,Matthew Dunn,M Earthrowl,A E Ellington,K A Evans,L M Faulkner,Matthew D. Francis,Adam Frankish,J Frankland,Lisa French,P Garner,J Garnett,Mohammed J. R. Ghori,L M Gilby,Christopher J. Gillson,Rebecca Glithero,Darren Grafham,M Grant,Susan M. Gribble,C Griffiths,Mark Griffiths,Rebekah Hall,K S Halls,S Hammond,Joanna Harley,E. Hart,Paul Heath,R Heathcott,S. Holmes,Philip Howden,Kevin L. Howe,Gareth R. Howell,Elizabeth J. Huckle,Sean Humphray,Matthew Humphries,Adrienne Hunt,Christopher M. Johnson,A Joy,M. Kay,Stephen Keenan,A M Kimberley,A. King,Gavin K. Laird,Cordelia Langford,S Lawlor,Daniel Leongamornlert,Margaret A. Leversha,Christine Lloyd,D. M. Lloyd,Jane E. Loveland,J Lovell,Sancha Martin,M Mashreghi-Mohammadi,Gareth Maslen,Lucy Matthews,O. T. McCann,S J McLaren,Kirsten McLay,Amanda McMurray,M. J F Moore,James C. Mullikin,David Niblett,T Nickerson,K L Novik,Karen Oliver,E K Overton-Larty,Anne Parker,R Patel,A. V. Pearce,A I Peck,Benjamin Phillimore,Sam Phillips,Robert W. Plumb,K M Porter,Y. Ramsey,S A Ranby,Catherine M. Rice,Mark T. Ross,S. Searle,Harminder Sehra,E Sheridan,C. D. Skuce,Sarah E. Smith,Michelle Smith,L Spraggon,S. Squares,Charles A. Steward,N Sycamore,G Tamlyn-Hall,J Tester,A J Theaker,Duncan W. Thomas,A Thorpe,Alan Tracey,A Tromans,B Tubby,Melanie M. Wall,J. M. Wallis,Anthony P. West,S S White,S. Whitehead,H Whittaker,A Wild,Dave Willey,T. E. Wilmer,Jonathan Wood,Paul Wray,J C Wyatt,L Young,R M Younger,David R. Bentley,Alan Coulson,Richard Durbin,Tim Hubbard,John Sulston,Ian Dunham,Jane Rogers,Stephan Beck +170 more
TL;DR: Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block, and detects recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection.
Journal ArticleDOI
The DNA sequence and comparative analysis of human chromosome 20.
Panos Deloukas,M Earthrowl,Darren Grafham,Marc Rubenfield,Lisa French,Charles A. Steward,Sarah Sims,Matthew Jones,S. Searle,Carol Scott,Kerstin Howe,Sarah E. Hunt,T D Andrews,James G. R. Gilbert,David Swarbreck,Jennifer L. Ashurst,A Taylor,J Battles,Christine P. Bird,R Ainscough,J P Almeida,R I S Ashwell,K D Ambrose,A K Babbage,C L Bagguley,J Bailey,Ruby Banerjee,K Bates,Helen Beasley,S Bray-Allen,A J Brown,J Y Brown,D C Burford,W Burrill,John Burton,Patrick Cahill,D Camire,Nigel P. Carter,J C Chapman,S Y Clark,G Clarke,C M Clee,S. M. Clegg,N Corby,Alan Coulson,Pawandeep Dhami,I Dutta,Matthew Dunn,L M Faulkner,Adam Frankish,J Frankland,P Garner,J Garnett,Susan M. Gribble,C Griffiths,Russell J. Grocock,Erik Gustafson,S Hammond,Joanna Harley,E. Hart,Paul Heath,T P Ho,B Hopkins,J Horne,Philip Howden,Elizabeth J. Huckle,C Hynds,Chris Johnson,David W. Johnson,A Kana,M. Kay,A M Kimberley,J K Kershaw,M Kokkinaki,Gavin K. Laird,S Lawlor,H M Lee,Daniel Leongamornlert,G Laird,Christine Lloyd,D. M. Lloyd,Jane E. Loveland,J Lovell,Stuart McLaren,Kirsten McLay,Amanda McMurray,M Mashreghi-Mohammadi,Lucy Matthews,Sarah Milne,T Nickerson,M Nguyen,E K Overton-Larty,Sophie Palmer,A. V. Pearce,A I Peck,Sarah Pelan,Benjamin Phillimore,K M Porter,Catherine M. Rice,A Rogosin,Mark T. Ross,Theologia Sarafidou,Harminder Sehra,Ratna Shownkeen,C. D. Skuce,Michelle Smith,L Standring,N Sycamore,J Tester,A Thorpe,W Torcasso,Alan Tracey,A Tromans,J Tsolas,Melanie M. Wall,J Walsh,H Wang,Keith Weinstock,Anthony P. West,David Willey,S. Whitehead,Laurens G. Wilming,Paul Wray,L Young,Yuan Chen,Ruth C. Lovering,Nicholas K. Moschonas,Reiner Siebert,Kim Fechtel,David Bentley,Richard Durbin,Tim Hubbard,Lynn Doucette-Stamm,Stephan Beck,Douglas Smith,Jane Rogers +135 more
TL;DR: Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.
Journal ArticleDOI
Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project
Roger Horton,Richard Gibson,Penny Coggill,Marcos Mateo Miretti,Richard J.N. Allcock,J P Almeida,Simon A. Forbes,James G. R. Gilbert,Karen Halls,Jennifer Harrow,E. Hart,Kevin L. Howe,David K. Jackson,Sophie Palmer,Anne N. Roberts,Sarah Sims,C. Andrew Stewart,James A. Traherne,Steve Trevanion,Laurens G. Wilming,Jane Rogers,Pieter J. de Jong,John F. Elliott,Stephen Sawcer,John A. Todd,John Trowsdale,Stephan Beck,Stephan Beck +27 more
TL;DR: The MHC Haplotype Project was to provide a comprehensively annotated reference sequence of a single, human leukocyte antigen-homozygous MHC haplotype and to use it as a basis against which variations could be assessed from seven other similarly homozygous cell lines, representative of the most common MHChaplotype in the European population.