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Roger Pettett
Researcher at Wellcome Trust Sanger Institute
Publications - 9
Citations - 6476
Roger Pettett is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Ensembl & Biological data. The author has an hindex of 9, co-authored 9 publications receiving 5853 citations. Previous affiliations of Roger Pettett include Wellcome Trust.
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Journal ArticleDOI
DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
Helen V. Firth,Shola M. Richards,A. Paul Bevan,Stephen Clayton,Manuel Corpas,Diana Rajan,Steven Van Vooren,Yves Moreau,Roger Pettett,Nigel P. Carter +9 more
TL;DR: An interactive web-based database called DECIPHER (Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources) which incorporates a suite of tools designed to aid the interpretation of submicroscopic chromosomal imbalance, inversions, and translocations.
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The Ensembl genome database project
Tim Hubbard,Daniel Barker,Ewan Birney,Graham Cameron,Yuan Chen,Louise Clark,Tony Cox,James Cuff,Val Curwen,Thomas A. Down,Richard Durbin,Eduardo Eyras,James G. R. Gilbert,Martin Hammond,Lukasz Huminiecki,Arek Kasprzyk,Heikki Lehväslaiho,Philip Lijnzaad,Craig Melsopp,Emmanuel Mongin,Roger Pettett,Matthew Pocock,Simon C. Potter,Alistair G. Rust,Esther Schmidt,Stephen M. J. Searle,Guy Slater,James Smith,William Spooner,Arne Stabenau,Jim Stalker,Elia Stupka,Abel Ureta-Vidal,Imre Vastrik,Michele Clamp +34 more
TL;DR: The Ensembl database project provides a bioinformatics framework to organise biology around the sequences of large genomes and is a comprehensive source of stable automatic annotation of the human genome sequence, with confirmed gene predictions that have been integrated with external data sources.
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DNA methylation profiling of human chromosomes 6, 20 and 22
Florian Eckhardt,Joern Lewin,Rene Cortese,Vardhman K. Rakyan,John Attwood,Matthias Burger,John Burton,Tony Cox,Robert L. Davies,Thomas A. Down,Carolina Haefliger,Roger Horton,Kevin L. Howe,David K. Jackson,Jan Kunde,Jan Kunde,Christoph Koenig,Jennifer Liddle,David Niblett,Thomas J. Otto,Roger Pettett,Stefanie Seemann,Christian Thompson,Tony West,Jane Rogers,Alex Olek,Kurt Berlin,Stephan Beck +27 more
TL;DR: Analysis of six annotation categories showed that evolutionarily conserved regions are the predominant sites for differential DNA methylation and that a core region surrounding the transcriptional start site is an informative surrogate for promoter methylation.
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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
Sally Bamford,Elisabeth Dawson,Simon A. Forbes,Jody Clements,Roger Pettett,Ahmet Dogan,Adrienne M. Flanagan,Jon W. Teague,P A Futreal,Michael R. Stratton,Richard Wooster +10 more
TL;DR: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer.
Journal ArticleDOI
An Overview of Ensembl
Ewan Birney,T. Daniel Andrews,Paul Bevan,Mario Caccamo,Yuan Chen,Laura Clarke,Guy Coates,James Cuff,Val Curwen,Tim J.R. Cutts,Thomas A. Down,Eduardo Eyras,Xosé M. Fernández-Suárez,Paul Gane,Brian Gibbins,James G. R. Gilbert,Martin Hammond,Hans-Rudolf Hotz,Vivek Iyer,Kerstin Jekosch,Andreas Kähäri,Arek Kasprzyk,Damian Keefe,Stephen Keenan,Heikki Lehväslaiho,Graham McVicker,Craig Melsopp,Patrick Meidl,Emmanuel Mongin,Roger Pettett,Simon C. Potter,Glenn Proctor,Mark Rae,Steve Searle,Guy Slater,Damian Smedley,James Smith,William Spooner,Arne Stabenau,James Stalker,Roy Storey,Abel Ureta-Vidal,K. Cara Woodwark,Graham Cameron,Richard Durbin,Anthony J. Cox,Tim Hubbard,Michele Clamp +47 more
TL;DR: The aims of Ensembl are to "widen" this biological integration to include other model organisms relevant to understanding human biology as they become available; to "deepen" this integration to provide an ever more seamless linkage between equivalent components in different species; and to provide further classification of functional elements in the genome that have been previously elusive.