P
Penny Coggill
Researcher at Wellcome Trust Sanger Institute
Publications - 27
Citations - 20504
Penny Coggill is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Major histocompatibility complex & Gene. The author has an hindex of 21, co-authored 27 publications receiving 19902 citations. Previous affiliations of Penny Coggill include Janelia Farm Research Campus.
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Journal ArticleDOI
The Pfam protein families database
Marco Punta,Penny Coggill,Ruth Y. Eberhardt,Jaina Mistry,John Tate,Chris Boursnell,Ningze Pang,Kristoffer Forslund,Goran Ceric,Jody Clements,Andreas Heger,Liisa Holm,Erik L. L. Sonnhammer,Sean R. Eddy,Alex Bateman,Robert D. Finn +15 more
TL;DR: The definition and use of family-specific, manually curated gathering thresholds are explained and some of the features of domains of unknown function (also known as DUFs) are discussed, which constitute a rapidly growing class of families within Pfam.
Journal ArticleDOI
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
Ravi Sachidanandam,David Weissman,Steven Schmidt,Jerzy M. Kakol,Lincoln Stein,Gabor T. Marth,Steve Sherry,James C. Mullikin,Beverley J. Mortimore,David Willey,Sarah E. Hunt,Charlotte G. Cole,Penny Coggill,Catherine M. Rice,Zemin Ning,Jane Rogers,David R. Bentley,Pui-Yan Kwok,Elaine R. Mardis,Raymond T. Yeh,Brian Schultz,Lisa Cook,Ruth Davenport,Michael Dante,Lucinda Fulton,LaDeana W. Hillier,Robert H. Waterston,John Douglas Mcpherson,Brian Gilman,Stephen F. Schaffner,William J. Van Etten,David Reich,John M. Higgins,Mark J. Daly,Brendan Blumenstiel,Jennifer Baldwin,Nicole Stange-Thomann,Michael C. Zody,Lauren Linton,Eric S. Lander,David Altshuler +40 more
TL;DR: This high-density SNP map provides a public resource for defining haplotype variation across the genome, and should help to identify biomedically important genes for diagnosis and therapy.
Journal ArticleDOI
InterPro in 2011: new developments in the family and domain prediction database
Sarah Hunter,Philip Jones,Alex L. Mitchell,Rolf Apweiler,Teresa K. Attwood,Alex Bateman,Thomas E. Bernard,David Binns,Peer Bork,Sarah W. Burge,Edouard de Castro,Penny Coggill,Matthew Corbett,Ujjwal Das,Louise C. Daugherty,Lauranne Duquenne,Robert D. Finn,Matthew Fraser,Julian Gough,Daniel H. Haft,Nicolas Hulo,Daniel Kahn,Elizabeth Kelly,Ivica Letunic,David M. Lonsdale,Rodrigo Lopez,Martin Madera,John Maslen,Craig McAnulla,Jennifer McDowall,Conor McMenamin,Huaiyu Mi,Prudence Mutowo-Muellenet,Nicola Mulder,Darren A. Natale,Christine A. Orengo,Sebastien Pesseat,Marco Punta,Antony F. Quinn,Catherine Rivoire,Amaia Sangrador-Vegas,Jeremy D. Selengut,Christian J. A. Sigrist,Maxim Scheremetjew,John Tate,Manjulapramila Thimmajanarthanan,Paul Thomas,Cathy H. Wu,Corin Yeats,Siew Yit Yong +49 more
TL;DR: An overview of new developments in the InterPro database and its associated software since 2009 is given, including updates to database content, curation processes and Web and programmatic interfaces.
Downregulation of Death-Associated Protein Kinase 1 (DAPK1 )i n Chronic Lymphocytic Leukemia
Aparna Raval,Stephan M. Tanner,John C. Byrd,Elizabeth Angerman,James D. Perko,Shih-Shih Chen,Michael R. Grever,David M. Lucas,Jennifer J. Matkovic,Thomas S. Lin,Thomas J. Kipps,Fiona Murray,Dennis D. Weisenburger,Warren G. Sanger,Jane F. Lynch,Mary Jansen,Yuko Yoshinaga,Richard Rosenquist,Pieter J. de Jong,Penny Coggill,Stephan Beck,Henry T. Lynch,Albert de la Chapelle,Christoph Plass +23 more
TL;DR: It is shown that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL.
Journal ArticleDOI
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
Aparna Raval,Stephan M. Tanner,John C. Byrd,Elizabeth Angerman,James D. Perko,Shih Shih Chen,Björn Hackanson,Björn Hackanson,Michael R. Grever,David M. Lucas,Jennifer J. Matkovic,Thomas S. Lin,Thomas J. Kipps,Fiona Murray,Dennis D. Weisenburger,Warren G. Sanger,Jane F. Lynch,Patrice Watson,Mary Jansen,Yuko Yoshinaga,Richard Rosenquist,Pieter J. de Jong,Penny Coggill,Stephan Beck,Henry T. Lynch,Albert de la Chapelle,Christoph Plass +26 more
TL;DR: In this article, the authors show that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL cases.