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Esther Schmidt
Researcher at European Bioinformatics Institute
Publications - 13
Citations - 8054
Esther Schmidt is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: BioPAX : Biological Pathways Exchange & Genome. The author has an hindex of 12, co-authored 13 publications receiving 7666 citations. Previous affiliations of Esther Schmidt include St. John's University.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
The Ensembl genome database project
Tim Hubbard,Daniel Barker,Ewan Birney,Graham Cameron,Yuan Chen,Louise Clark,Tony Cox,James Cuff,Val Curwen,Thomas A. Down,Richard Durbin,Eduardo Eyras,James G. R. Gilbert,Martin Hammond,Lukasz Huminiecki,Arek Kasprzyk,Heikki Lehväslaiho,Philip Lijnzaad,Craig Melsopp,Emmanuel Mongin,Roger Pettett,Matthew Pocock,Simon C. Potter,Alistair G. Rust,Esther Schmidt,Stephen M. J. Searle,Guy Slater,James Smith,William Spooner,Arne Stabenau,Jim Stalker,Elia Stupka,Abel Ureta-Vidal,Imre Vastrik,Michele Clamp +34 more
TL;DR: The Ensembl database project provides a bioinformatics framework to organise biology around the sequences of large genomes and is a comprehensive source of stable automatic annotation of the human genome sequence, with confirmed gene predictions that have been integrated with external data sources.
Journal ArticleDOI
Reactome: a knowledgebase of biological pathways.
Geeta Joshi-Tope,Marc Gillespie,Marc Gillespie,Imre Vastrik,Peter D'Eustachio,Peter D'Eustachio,Esther Schmidt,B. de Bono,Bijay Jassal,Gopal R. Gopinath,Guanming Wu,Lisa Matthews,Suzanna E. Lewis,Ewan Birney,Lincoln Stein +14 more
TL;DR: The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as the cell cycle.
Journal ArticleDOI
Reactome knowledgebase of human biological pathways and processes.
Lisa Matthews,Gopal Gopinath,Marc Gillespie,Michael Caudy,David B. Croft,Bernard de Bono,Phani V. Garapati,Jill Hemish,Henning Hermjakob,Bijay Jassal,Alexander Kanapin,Suzanna E. Lewis,Shahana S. Mahajan,Bruce May,Esther Schmidt,Imre Vastrik,Guanming Wu,Ewan Birney,Lincoln Stein,Peter D'Eustachio +19 more
TL;DR: Improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa, Drosophila and Gallus gallus.
Journal ArticleDOI
Reactome: a knowledge base of biologic pathways and processes
Imre Vastrik,Peter D'Eustachio,Peter D'Eustachio,Esther Schmidt,Geeta Joshi-Tope,Gopal R. Gopinath,David Croft,Bernard de Bono,Marc Gillespie,Marc Gillespie,Bijay Jassal,Suzanna E. Lewis,Lisa Matthews,Guanming Wu,Ewan Birney,Lincoln Stein +15 more
TL;DR: This work uses Reactome to infer equivalent reactions in multiple nonhuman species, and presents data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae.