Rohidas Arote

TL;DR: The results indicate that the CHI-g-PEI copolymer has potential as a gene carrier in vitro and had low cytotoxicity, compared to PEI 25K from cytot toxicity assays.

TL;DR: In this paper, a review of the QbD approach, its historical background, and regulatory needs are discussed, in detail explanation of elements of QdD i.e. method intent, design of experiment, and risk assessment is given.

TL;DR: These PEAs can be used as most efficient polymeric vectors which provide a versatile platform for further investigation of structure property relationship along with the controlled degradation, significant low cytotoxicity and high transfection efficiency.

TL;DR: Results suggest that Gal-PEG-CHI-g-PEI, which has improved transfection efficiency and hepatocyte specificity both in vitro and in vivo, may be useful for gene therapy.

TL;DR: GC-g-PEI can be used in gene therapy to improve transfection efficiency and hepatocyte specificity in vitro and in vivo, and showed good DNA-binding ability and superior protection of DNA from nuclease attack and had low cytotoxicity compared to PEI 25K.