R
Ronald G. Tompkins
Researcher at Harvard University
Publications - 531
Citations - 44641
Ronald G. Tompkins is an academic researcher from Harvard University. The author has contributed to research in topics: Burn injury & Poison control. The author has an hindex of 93, co-authored 526 publications receiving 41859 citations. Previous affiliations of Ronald G. Tompkins include University of Toronto & Tulane University.
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Journal ArticleDOI
Adipocyte apoptosis after burn injury is associated with altered fat metabolism
Shingo Yasuhara,Masao Kaneki,Hiroki Sugita,Michiko Sugita,Akihiro Asai,Nita Sahani,Jin Young Chon,Ronald G. Tompkins,J. A. Jeevendra Martyn +8 more
TL;DR: Epididymal adipose tissue showed increased apoptosis manifested by the positive TUNEL staining and increased DNA fragmentation by enzyme-linked immunoassay at day 3 and 7 after burn injury, correlated with decrease in DNA content and tissue weight in the epidydimis.
Journal ArticleDOI
Detecting differential protein expression in large-scale population proteomics
So Young Ryu,Wei-Jun Qian,David G. Camp,Richard D. Smith,Ronald G. Tompkins,Ronald W. Davis,Wenzhong Xiao +6 more
TL;DR: A Significance Analysis for Large-scale Proteomics Studies (SALPS) that handles missing peptide intensity values caused by the two mechanisms mentioned above, and has a robust performance in both simulated data and proteomics data from a large clinical study.
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An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.
Mohammed A. S. Khan,Mohammed F. Khan,Shizuka Kashiwagi,William R. Kem,Shingo Yasuhara,Masao Kaneki,Ronald G. Tompkins,J. A. Jeevendra Martyn +7 more
TL;DR: The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via &agr;7AChRs upstream of Stat-3 and -5 pathways and is associated with myonuclear accretion, possibly via MyoD and Pax7 expression.
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Thermal injury-induced changes in the rat intestine brush border cytoskeleton.
TL;DR: It is suggested that disruption of the brush border cytoskeleton may, in part, be responsible for the loss of intestinal barrier function after thermal injury in animal models.
Journal ArticleDOI
Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle
Harumasa Nakazawa,Marina Yamada,Tomokazu Tanaka,Joshua A. Kramer,Yong-Ming Yu,Alan Fischman,J. A. Jeevendra Martyn,Ronald G. Tompkins,Masao Kaneki +8 more
TL;DR: It is demonstrated that burn increased FTase expression and protein farnesylation along with insulin resistance, metabolic alterations and inflammatory response in mouse skeletal muscle, all of which were prevented by FTI-277 treatment.