R
Ronald G. Tompkins
Researcher at Harvard University
Publications - 531
Citations - 44641
Ronald G. Tompkins is an academic researcher from Harvard University. The author has contributed to research in topics: Burn injury & Poison control. The author has an hindex of 93, co-authored 526 publications receiving 41859 citations. Previous affiliations of Ronald G. Tompkins include University of Toronto & Tulane University.
Papers
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Journal ArticleDOI
Clinical Microfluidics for Neutrophil Genomics and Proteomics
Kenneth T. Kotz,Wenzong Xiao,Wenzong Xiao,Carol L. Miller-Graziano,Wei-Jun Qian,Aman Russom,Elizabeth A. Warner,Lyle L. Moldawer,Asit De,Paul E. Bankey,Brianne O. Petritis,David G. Camp,Alan E. Rosenbach,Jeremy Goverman,Shawn P. Fagan,Bernard H. Brownstein,Daniel Irimia,Weihong Xu,Julie Wilhelmy,Michael N. Mindrinos,Richard D. Smith,Ronald W. Davis,Ronald G. Tompkins,Mehmet Toner +23 more
TL;DR: The preliminary results from a small cohort of subjects in this study and healthy controls show a unique time-dependent gene expression pattern clearly demonstrating the ability of this tool to discriminate temporal transcriptional events of neutrophils within a clinical setting.
Journal ArticleDOI
A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.
R. Huang,Tom Barber,Martin A. Schmidt,Ronald G. Tompkins,Mehmet Toner,Diana W. Bianchi,Ravi Kapur,W. L. Flejter +7 more
TL;DR: The development of a high‐throughput and highly efficient microfluidic device for isolating rare NRBCs from maternal blood is reported.
Journal ArticleDOI
Quantitative Proteome Analysis of Human Plasma following in Vivo Lipopolysaccharide Administration Using 16O/18O Labeling and the Accurate Mass and Time Tag Approach
Wei-Jun Qian,Matthew E. Monroe,Tao Liu,Jon M. Jacobs,Gordon A. Anderson,Yufeng Shen,Ronald J. Moore,David J. Anderson,Rui Zhang,Steve E. Calvano,Stephen F. Lowry,Wenzhong Xiao,Lyle L. Moldawer,Ronald W. Davis,Ronald G. Tompkins,David G. Camp,Richard D. Smith,Henry V. Baker,Paul E. Bankey,Timothy R. Billiar,Bernard H. Brownstein,Irshad H. Chaudry,J. Perren Cobb,Adrian Fay,Robert J. Feezor,Brad Freeman,Richard L. Gamelli,Nicole S. Gibran,Brian G. Harbrecht,Doug Hayden,David N. Herndon,Jureta W. Horton,John L. Hunt,Jeffrey L. Johnson,Krzystof Laudanski,James A. Lederer,Tanya Logvinenko,Ronald V. Maier,John A. Mannick,Bruce A. McKinley,Carol L. Miller-Graziano,Joseph P. Minei,Michael N. Mindrinos,Ernest E. Moore,F. A. Moore,Avery B. Nathens,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,David A. Schoenfeld,Michael B. Shapiro,Robert L. Sheridan,Geoffrey M. Silver,Scott Somers,Mehmet Toner,H. Shaw Warren,Michael West,Steven E. Wolf,Martin L. Yarmush,Vernon R. Young +59 more
TL;DR: An initial demonstration of proteome-wide quantitative analysis of human plasma using postdigestion trypsin-catalyzed 16O/18O peptide labeling, two-dimensional LC-FTICR mass spectrometry, and the accurate mass and time (AMT) tag strategy to identify and quantify peptides/proteins from complex samples is described.
Journal ArticleDOI
Continuous flow microfluidic device for rapid erythrocyte lysis.
TL;DR: A microfluidic lysis device is developed that can achieve complete lysis of erythrocytes and approximately 100% recovery of leukocytes where the cells are exposed to an isotonic lysis buffer for less than 40 s, after which theLeukocytes are immediately returned to physiological conditions.
Journal ArticleDOI
Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
Shailesh Agarwal,Shawn Loder,Cameron Brownley,David Cholok,Laura Mangiavini,John Li,Christopher Breuler,Hsiao H. Sung,Shuli Li,Kavitha Ranganathan,Joshua Peterson,Ronald G. Tompkins,David N. Herndon,Wenzhong Xiao,Dolrudee Jumlongras,Bjorn R. Olsen,Thomas A. Davis,Yuji Mishina,Ernestina Schipani,Benjamin Levi +19 more
TL;DR: It is demonstrated that Hypoxia inducible factor-1α (Hif1α), a key mediator of cellular adaptation to hypoxia, is highly expressed and active in three separate mouse models: trauma- induced, genetic, and a hybrid model of genetic and trauma-induced HO.